Nicollier was born September 2, 1944. After graduating from the Gymnase de Lausanne (high school) in Lausanne in 1962, he studied physics at the University of Lausanne and received a BSc degree in 1970. He then worked as a graduate scientist from 1970 to 1973 at the Institute of Astronomy at the University and at the Geneva Observatory, before obtaining a MSc degree in astrophysics from the University of Geneva in 1975. In parallel, he became a Swiss Air Force pilot in 1966, in the Fliegerstaffel 5 on Hawker Hunter where he holds a commission as captain, and has logged 5,600 hours flying time, including 4,000 hours in jet aircraft. Later, in 1988, he graduated as a test pilot from the Empire Test Pilot's School in Boscombe Down, United Kingdom.