Schiffer appeared on the November 1999 millennium cover of Vogue as one of the "Modern Muses". Named one of the most beautiful women in the world, her ability to appeal to a global audience assured an internationally successful career spanning over 25 years. Other magazines Schiffer has appeared on the covers of include Vanity Fair, Rolling Stone, People, Harper's Bazaar, Elle, Cosmopolitan and Time. Schiffer has walked in fashion shows for numerous fashion houses, including Versace, Karl Lagerfeld, Chloé, Yves Saint Laurent, Christian Dior, Fendi, Michael Kors, Dolce & Gabbana, Ralph Lauren, Balmain, Louis Vuitton, Chanel and Valentino.