In 1994, she began acting a main role of Karabo Moroka, the wife of Tau Mogale and sister to Archie Moroka, in the most popular South African soap opera, Generations. She starred alongside Menzi Ngubane, Slindile Nodangala and Sophie Ndaba. In 2010, after playing the lead role of Karabo Moroka for 16 years, Connie announced her departure from Generations “to purse other career options”. Ferguson left Generations on a good note as she returned to the soapie four years later to help relaunch Generations: The Legacy.

Ferguson was married to fellow actor Neo Matsunyane from 1993 to 1998 and has a daughter with him, Lesedi Matsunyane (born 31 December 1992). In November 2001, 3 years after her divorce with Matsunyane, she married actor and director Shona Ferguson. The couple has a daughter, Alicia Angel Ferguson (born 7 June 2002).

Ferguson launched a fragrance called True Self in 2008, and a lotion in 2014.

After her 2010 departure from Generations, she went on to star in the lead role of the M-Net telenovela The Wild, which was shot at an exotic South African game farm. She co-starred with her real-life husband until its cancellation in April 2013.

Connie and her husband, Shona, launched the television company Ferguson Films in 2010. Their first production, Rockville, was commissioned by M-Net three years later. Other productions include iGazi, The Gift, The Throne, The Queen, The River and The Imposter. The couple often appear in their own productions; for example, Connie plays the role of Harriet Khoza on The Queen.

The Queen was nominated in several categories at the South African Film and Television Awards in 2018.