Talbot lives in Streetly, in the West Midlands with her mother, Sharon, her father Gavin, her older brother Josh, and her older sister Mollie. In 2006, she sang at her late grandmother’s funeral. Connie and her brother both support Wolverhampton Wanderers.

In October 2007, Talbot signed with the Rainbow Recording Company for a six-figure deal. Rainbow Recording Company, an offshoot of record label Rhythm Riders made specifically for Talbot, was due to release Talbot’s first album on 26 November 2007. It was later reported that the album was named Over the Rainbow, and the first single, “Over the Rainbow”/”White Christmas”, would be released on 3 December 2007. Experts predicted that she had a good chance of getting the Christmas number one, but the single was cancelled in favour of an album-first release. Before the album was released, there was much speculation about Talbot and the album, with music experts describing her as potentially being “the next Charlotte Church”. The team behind the album consisted of John Arnison, who also managed Gabrielle and Billy Ocean, and Marc Marot, former managing director of Island Records. It was produced and mixed by Simon Hill and Rob May.

The album was released on 26 November 2007 and was certified gold in early December, with Talbot being presented a gold disc by Phillip Schofield on This Morning. Initially, 50,000 copies of the album were pressed, but an additional 120,000 had to be made after the album sold out in days.

In late 2007, public appearances by Talbot included headlining the Great Bridge Christmas and Winter Festival, which local police threatened to cancel unless crowds clamouring to reach the tent in which Talbot was performing could be brought under control. At the event, on 7 December 2007, Talbot said “I love it here, it’s brilliant, really fun”, but had to be ushered off-stage by the police. Talbot performed publicly in Walsall’s HMV store, and in Birmingham’s Centenary Square. TV appearances included GMTV and Channel 5 news, both on 26 November 2007. According to her mother, Talbot has received offers for film roles. Sharon said “[Talbot]’s been sent a script, I haven’t had a good look at it yet but it’s really exciting … Connie’s a singer, not an actress, so we’ll see what happens. It’s completely up to her whether or not she wants to do it. I can’t believe it, though.”

The album was re-released on 16 June 2008, but was available for pre-order in May, with three new tracks to replace its Christmas-themed songs. The first single from the album, “Three Little Birds”, was released in June 2008. In April and May 2008, Talbot toured Asia to promote Over the Rainbow. Asian press attributed her success to her videos on YouTube, with the Sun.Star mentioning that her most viewed video had been watched over 14 million times, and The Straits Times saying that videos of Talbot’s performances have been watched over 30 million times. The tour made stops in South Korea, Taiwan, Hong Kong and Singapore, and Talbot and her family returned to England in late May. Following the tour, it was reported that the album had reached number one on the charts in Taiwan, South Korea and Hong Kong, as well as reaching number three in Singapore. After the tour, Talbot travelled to Poland, where she performed on television.

In August 2008, it was announced that Talbot had signed a contract with Data Design Interactive for production of a video game on the Wii console. The game was to feature 15 songs from Over the Rainbow, allowing players to sing along with a computer-generated image of Talbot or against other players in a karaoke mode. Talbot re-recorded the album for the game. The game was scheduled for release in the first quarter of 2009, and was to be called Connie Talbot: Over the Rainbow.

In November 2008, it was announced that Talbot had produced a series of new songs for an album. Recorded in her bedroom studio, Connie Talbot’s Christmas Album was released on 24 November. It is a Christmas themed album, featuring, according to Talbot’s official website, “a mix of classics and modern Christmas tunes”. News was also released of a one-off Christmas special to be shown on ITV1 in the days leading up to Christmas, featuring footage of Talbot’s journey to America and a “secret concert” at her primary school. The documentary, Christmas with Connie, was shown on ITV Central on 18 December. Talbot appeared at Walsall’s HMV branch shortly after the release of her Christmas Album to sign copies and meet fans. She then embarked on a promotional tour making stops around the world, which included a performance at Ewha Womans University in Korea, and a performance on the “A Heart for Children” television charity gala in Berlin, Germany. She returned home in mid December, to have “a quiet family Christmas”.

In April 2009, Talbot again travelled to the US to publicise her new single, a cover of “I Will Always Love You”. The single was released in the US on 7 April, along with a newly recorded “You Raise Me Up”. Talbot then traveled to the US on 30 April, and returned on 2 May. Appearances included a performance on Good Day New York on Fox Broadcasting Company’s WNYW.

Talbot’s third album, Connie Talbot’s Holiday Magic, was released on 20 October 2009 in the United States and on 30 November 2009 in the United Kingdom. The United States album is dedicated to the Toys for Tots campaign, of which Talbot has been named the child ambassador. In a statement, Bill Grein, Vice-President of the Marine Toys for Tots Foundation, said:

Talbot opened a special concert celebrating South Korea’s hosting of the G20 summit of world leaders in 2010. She performed for her largest ever audience when she performed on Chinese state television for the Chinese new-year in 2011. Viewing figures for the event were estimated to be around 400 million.

The video was also picked up by PerezHilton.com. After the death of Whitney Houston, Talbot posted a cover version of “Run to You” as a tribute. The video received attention from around the world. In November 2011, she released “Beautiful World” as a single on iTunes. The song was written by Talbot when she was seven. A demo of the track was placed on YouTube, and became the 39th most watched video in the world on the day it was uploaded.

Talbot toured with the Young Voices choir for a second year in early 2013, performing at venues across the UK. The African Children’s Choir also took part in these events. Her song “Let’s Get Along”, written by Kipper, was featured on ONE Campaign’s agit8 Spotify album that July. Talbot also featured in the song “Building Bridges”, which also made the agit8 album, together with Jordan Jansen.

In October 2013, Talbot’s vocals featured in the theme song of the newly-released video game Rain, and she appeared as a special guest at the African Children’s Choir concert in Walsall, UK. It was announced that Talbot would be an ambassador for the African Children’s Choir and have a school named after her.

In 2014, she performed two concerts in South Korea (Osan and Seoul) in late April, shortly after the Sewol ferry tragedy. She performed with yellow ribbons to show her respect for the families of the victims. The proceeds from at least one of the concerts were donated to the fundraising efforts in support of the families of the victims. In July, a DVD and Blu-ray was released of her concerts in Hong Kong and Taiwan during her Beautiful World tour in 2012. It features live performances of the songs from Beautiful World, and two additional songs, “I Will Always Love You” and “Over the Rainbow”.

On 17 November 2014, Talbot released the five-song EP Gravity, containing the original songs “Gravity” and “Inner Beauty”, with the latter also appearing as an instrumental acoustic version.

On 19 February 2016, the release of digital single “Shut Up (Move On)” was announced. The single is taken from Talbot’s studio album Matters to Me, a 13-track album with a bonus track available only on iTunes. The album was released on 25 March 2016.

On 11 May 2017, Connie Talbot released a song called “Good to Me”, which she stated is “about a person who I admired, respected and who taught me so much. That person sadly passed away and I wrote this song from my heart.” On 13 October 2017, Connie released a video for the song “Rumours”.

In April 2019 she collaborated with Boyce Avenue covering the Jonas Brothers song “Sucker”.

On 31 August 2019 Talbot took part in Britain’s Got Talent: The Champions with an original composition, “Never Give Up on Us”. The song was released the same day. By the following day, the song had reached number eight on the U.K. iTunes chart.

On 27 January 2020 she competed on America’s Got Talent: The Champions, where she performed her romantic original song “I Would” on the piano.