In 1868, Vanderbilt fell into a dispute with Daniel Drew, who had become treasurer of the Erie Railway. To get revenge, he tried to corner Erie stock, which led to the so-called Erie War. This brought him into direct conflict with Jay Gould and financier James Fisk Jr., who had just joined Drew on the Erie board. They defeated the corner by issuing "watered stock" in defiance of state law, which restricted the number of shares a company could issue. But Gould bribed the legislature to legalize the new stock. Vanderbilt used the leverage of a lawsuit to recover his losses, but he and Gould became public enemies.
Following his wife Sophia's death in 1868, Vanderbilt went to Canada. On August 21, 1869, in London, Ontario, he married a cousin from Mobile, Alabama, with the name — unusual for a woman — of Frank Armstrong Crawford.