On April 12, 2012, Booker saved a woman from a house fire, suffering smoke inhalation and second-degree burns on his hands in the process. Newark Fire Chief John Centanni said that Booker's actions possibly saved the woman's life. After Hurricane Sandy destroyed much of the shoreline areas of New Jersey and New York in late October 2012, Booker invited Newarkers without electrictiy and similar services to eat and sleep in his home. In February 2013, responding to a Twitter post, Booker helped a nervous constituent propose to his girlfriend. Booker rescued a dog from freezing temperatures in January 2013 and another dog that had been abandoned in a cage in July 2013.
On November 20, 2012, a melee occurred at a Newark City Council meeting attended by Booker. The nine-seat council was to vote on the successor to the seat vacated by newly elected U.S. Representative Donald M. Payne, Jr. Booker's opponents on the council, including Ras Baraka, sought to appoint John Sharpe James, son of the former mayor, while Booker and his supporters favored Shanique Speight. Booker attended the meeting to deal with the eventuality of the lack of a quorum or a tie vote, in which state law would allow him to cast a deciding vote. After Baraka was refused an opportunity to address the council by acting Council President Anibal Ramos, Jr., Baraka and two other council members walked away in protest. Booker cast the deciding vote for Speight. Supporters of James stormed the stage and were held back by riot police, who eventually used pepper spray on some members of the crowd. Baraka later blamed Booker for inciting the disturbance, while Booker refused comment to the media after the vote.
In December 2012, after discussions with a constituent about New Jersey's Supplemental Nutrition Assistance Program (SNAP), Booker began a week-long challenge attempting to live on a food budget of $30 per week—the amount SNAP recipients receive. When critics noted that the very name of the SNAP program shows that it is intended to "supplement" an individual's food budget, not be its sole source, Booker replied that his aim was to spark a discussion about the reality that many Americans rely solely on food stamps to survive.
On December 20, 2012, Booker announced that he would explore running for the U.S. Senate seat that was then occupied by Frank Lautenberg in the 2014 election, ending speculation that he would challenge Governor Chris Christie in the 2013 gubernatorial election. On January 11, 2013, Booker filed papers to form a campaign committee, without announcing whether he would run. Roughly one month later, incumbent Lautenberg—then 89 years of age—announced that he would not seek reelection in 2014.
Booker generated controversy on May 12, 2012, when he appeared on Meet The Press as a surrogate for the reelection campaign of Barack Obama and made remarks that were critical of that campaign. Booker said that the attacks on Republican presidential candidate Mitt Romney's record at Bain Capital were "nauseating to me on both sides. It's nauseating to the American public. Enough is enough. Stop attacking private equity. Stop attacking Jeremiah Wright." The comments were subsequently used by the Romney campaign against Obama. Booker made follow-up comments clarifying that he believed Obama's attacks on Romney's record at Bain were legitimate but did not retract his point about attacking private equity in general. Two weeks later, Booker's communications director Anne Torres tendered her resignation, although she maintained it was unrelated to Meet the Press.
In 2012, Booker and tech executives Sarah Ross and Nathan Richardson formed Waywire, a company focused on video sharing technology. Early investors included Oprah Winfrey, Eric Schmidt, Jeff Weiner, and Troy Carter. After Booker's relationship to Waywire was discussed in a front-page The New York Times story, board member Andrew Zucker stepped down from his position. Shortly thereafter, Waywire CEO Nathan Richardson departed the business as the company shifted its focus from content creation to content curation. In August 2013, Booker told NBC News he intended to resign from the Waywire board and put his holdings in a trust if elected to the Senate; by September, he had resigned his place on the board and donated his share of the company to charity. Waywire was sold to another video curation business the following month.