On January 15, Sutton was moved into the Pro Bowl roster as an alternate, replacing the injured DeAndre Hopkins, who opted to not play in the game due to a rib injury suffered in a Divisional Round playoff game versus the Kansas City Chiefs. It was Sutton’s first Pro Bowl selection, and with the selection, Sutton became the fastest Broncos wide receiver to earn a Pro Bowl nod, accomplishing it in just his second season in the NFL, breaking Demaryius Thomas’s record of three seasons with his first Pro Bowl nod in 2012 after being drafted in 2010.

Sutton played in two games as a true freshman at SMU in 2014, before suffering an injury and taking a medical redshirt. As a redshirt freshman in 2015, he started all 12 games, recording 49 receptions for 862 yards and nine touchdowns. After the season he played in three games for SMU’s basketball team. As a sophomore in 2016, Sutton started all 12 games and had 76 receptions for 1,246 yards and 10 touchdowns. Sutton considered entering the 2017 NFL Draft, but instead, he decided to return to college for his redshirt junior year. On December 22, 2017, Sutton officially declared that he would enter the 2018 NFL Draft after completing his junior year.

In Week 1 against the Oakland Raiders on Monday Night Football, Sutton caught seven passes for 120 yards in the 24–16 loss. In Week 4 against the Jacksonville Jaguars, Sutton caught six passes for 62 yards and two touchdowns in the 26–24 loss. In Week 5 against the Los Angeles Chargers, Sutton caught four passes for 92 yards, including a 70-yard receiving touchdown, as the Broncos won their first game of the season by a score of 20–13. In Week 11 against the Minnesota Vikings, Sutton caught five passes for 113 yards in the 27–23 loss In Week 13 against the Los Angeles Chargers, Sutton four catches for 74 yards and rookie quarterback Drew Lock’s first two touchdown passes in the NFL during the 23-20 victory. Overall, in the 2019 season, Sutton recorded 72 receptions for 1,112 receiving yards and six receiving touchdowns.

After missing Week 1 with a shoulder injury, Sutton made his 2020 debut the following week against the Pittsburgh Steelers. During the game, Sutton caught 3 passes for 66 yards before exiting the game with a knee injury. The next day, an MRI confirmed that Sutton suffered a torn ACL and he was placed on season-ending injured reserve on September 22, 2020.