Capotondi debuted in cinema in 1995 with the comedy Vacanze di Natale '95. Between 1993 and 2006 she worked mostly in television, starring in 2004–2006 in the series Orgoglio, aired on Rai Uno. She gained additional exposure in the film Notte prima degli esami (2006), in which she starred as a main character alongside Nicolas Vaporidis. In 2009 Capotondi played the Austrian Empress Elisabeth of Bavaria in the ZDF/Rai Uno/ORF co-production Sissi.
