On June 30, 2007, Renn married her longtime boyfriend Gregory Vrecenak at the Church of St. Ignatius Loyola in Manhattan, New York. Fashion portraits of her wedding were taken by photographer Brian Boulos. In mid-2009 the couple ended their marriage. Renn currently resides in Brooklyn, New York.

Renn is also notable for appearing in back-to-back campaigns in 2007 wearing big crayons and regular-sized (not specifically plus-size) clothing for Spanish retailer Mango; her photos appearing amid those of smaller models and without notation regarding her larger size, a rare occurrence in conventional apparel advertising.

Renn’s first book, Hungry, was co-authored by Marjorie Ingall and released on September 8, 2009. Renn reported for Glamour at New York Fashion Week 2010 on the fall collections. As of 2012, Renn’s yearly income was in the high six figures.

In November 2010, Renn said she had lost weight through hiking and yoga, and that her dress size dropped to a US 8.

In 2011, Renn became the face of the spring/summer campaign for Jimmy Choo and the spring/summer MR Denim Collection by Marina Rinaldi, a plus-size jeans collection.

She has appeared in editorials for American, Australian, Italian, French, German, Spanish, Japanese, Latin American, and Teen Vogue, Italian Elle, Russian, Australian and American Harper’s Bazaar, Glamour, V, i-D and Vanity Fair. Renn also appeared in the 2012 Sports Illustrated Swimsuit Issue.