In 2007, Caruso was asked by Steven Spielberg to direct Disturbia. The movie was Caruso's first big hit, grossing over $117 million on a $20 million budget. It starred Shia LaBeouf, Sarah Roemer, David Morse, Aaron Yoo, and Carrie-Anne Moss. It was released April 13, 2007 in theaters and on DVD August 7. Eagle Eye was Caruso's second collaboration with producer Spielberg and actor LaBeouf. It also starred Michelle Monaghan, Billy Bob Thornton, Rosario Dawson and was released in theaters September 26, 2008. Critical reactions were mixed to negative but, on its opening weekend the movie grossed $29.1 million in 3,510 theaters in the United States and Canada. As of 2017, it has grossed $201 million worldwide with a movie budget of $80 million.
He was a guest judge on the Fox reality television show On the Lot for the episode of May 28 and 29 in 2007. Caruso directed his first music video in 2007 for the song "Don't Make Me Wait" by This World Fair. In 2009, he directed the music video for Airborne Toxic Event's song "Sometime Around Midnight".