For 2015, Patrick again stayed with Stewart-Haas Racing. She began her season in the Sprint Unlimited by finishing tenth after escaping with collateral damage from a multi-car accident. Patrick started at the back of the field for the season-opening Daytona 500 and finished 21st. After scoring two top-tens (seventh at the STP 500 at Martinsville Speedway and ninth at the Food City 500 at Bristol Motor Speedway), she eclipsed Janet Guthrie for the most top tens by a woman in Sprint Cup Series history. Patrick led two laps of the Quicken Loans 400 at Michigan International Speedway during the pit stop cycle, and finished 16th, and at the Quaker State 400, she became the first woman to start a hundred Cup Series races. At the Fall Martinsville race, she had twenty-five owner and drivers points deducted, was fined $50,000, and put on probation by NASCAR until the end of 2015 for an intentional retaliatory crash against David Gilliland. In 36 races, Patrick scored 716 points, placing her 24th in the drivers' standings, the highest of her career. She had two top-ten finishes, an average finish of 23.5, and failed to finish four times.
Patrick made her acting debut in the February 10, 2010, episode of CSI: NY where she played a race car driver suspected of murder. She also voiced herself in a cameo role in The Simpsons episode "How Munched Is That Birdie in the Window?". Patrick appears as a playable guest character in the video game Sonic & All-Stars Racing Transformed, providing her own voice and appeared in the game's commercial. She also appeared in Archie Comics' Sonic Universe #45, which adapted some of the game storyline. Fox NASCAR hired Patrick on February 21, 2015, as a booth analyst for Xfinity Series races. She provided commentary for the race at Michigan. Patrick also voices the race car character Rally in Nickelodeon's Blaze and the Monster Machines 2016 animated series. In June 2017, she joined Fox's Cup driver-only broadcast of the Xfinity Series race at Pocono Raceway, working in the studio alongside Denny Hamlin. A documentary entitled Danica which chronicles Patrick's professional and personal life premiered on November 8 on Epix. Her second book, Pretty Intense, was released on December 26. Patrick had a cameo role in Maroon 5's "Girls Like You" featuring Cardi B. On 18 July, she became the first woman to host the ESPY Awards. Patrick was a studio analyst for NBC's broadcast of the Indianapolis 500 in 2019 and 2020. In August 2019, she launched a weekly podcast called Pretty Intense in which she discusses success and spirituality with guests.