In 2006, he appeared as a guest in the successful Australian series Home and Away where he played the firefighter Dave Elder.

In 2011, he joined the cast of the series Crownies where he played Conrad De Groot, the fiancé of the lawyer Tatum Novak (Indiana Evans), until the end of the series the same year. The same year he appeared in the movie Entwined where he played Aiden.

In 2012, it was announced that he would join the cast of the American series Last Resort as James King, a petty officer of the U.S Navy, and a Navy SEAL. In the series he appeared with Andre Braugher, Scott Speedman, Autumn Reeser and Daisy Betts.

From 2014 to 2018, Lissing appeared in the Hallmark Channel series When Calls the Heart as Canadian Mountie Jack Thornton. He chose to leave the role at the end of Season 5 and his character was killed off.

In 2016, Lissing appeared alongside Jessica Lowndes in Hallmark Channel’s A December Bride as the character Seth. In 2018, he and Brooke D’Orsay starred in the channel’s film Christmas in Love.