Huston has been married twice. His first marriage was in 1989 to Academy Award nominee Virginia Madsen; they divorced in 1992. He married his second wife, Katie Jane Evans, in 2001 and they separated in 2006. Evans took her own life in October 2008 before the divorce was finalized. They had one daughter named Stella. He dated his Magic City co-star Olga Kurylenko for approximately a year.

His breakthrough acting performance is considered to have been in the independent film Ivans Xtc. The Bernard Rose feature was nominated for several Independent Spirit Awards in 2003, including Best Male Performance for Huston’s portrayal of Hollywood talent agent Ivan Beckman. Huston has worked nonstop as an actor ever since.

Soon after Ivans Xtc, Huston worked on Martin Scorsese’s The Aviator with Leonardo DiCaprio and Alec Baldwin. The ensemble cast was nominated for a 2004 SAG Award. In 2006, Huston received the Golden Satellite Award for Best Supporting Actor for his performance as Sandy Woodrow in Fernando Meirelles’ The Constant Gardener. That year, Huston also starred in the critically acclaimed Australian western The Proposition, with Guy Pearce and Emily Watson. The film premiered at the Sundance Film Festival.

Huston played gangster Ben “The Butcher” Diamond on Mitch Glazer’s Magic City on the Starz network from 2012 to 2013. He was nominated for the Golden Globe Award for Best Supporting Actor – Series, Miniseries or Television Film in 2013. Later that year, he portrayed The Axeman in a recurring role on American Horror Story: Coven.