In 2009, he was placed third in the "Top 100 DJs" poll by DJ Magazine, and was elected "Best House DJ" by DJ Awards in 2008. Since April 2009, Guetta had his own radio show on the internet radio station RauteMusik on Saturday evening. The show was afterwards moved into Radio 538, being aired every Friday evening after Tiësto's Club Life.
Guetta's fourth studio album, One Love, was released in August 2009. Its first single "When Love Takes Over", which featured Kelly Rowland, peaked at #1 on the UK Singles Chart and topped many other countries worldwide, selling over 5,5 million copies worldwide. His second single from the album, "Sexy Bitch" featuring Akon, became his second #1 in the UK. "One Love" featuring Estelle, "Memories" featuring Kid Cudi and "Gettin' Over You" featuring Chris Willis, Fergie and LMFAO followed. As of May 2011 the album had sold three million copies worldwide. Guetta's fourth studio album One Love was nominated as "Best Electronic/Dance Album" at the 52nd Annual Grammy Awards. His song "When Love Takes Over" featuring American R&B singer Kelly Rowland received two nominations; Best Dance Recording and Best Remixed Recording, Non-Classical, and won the latter. After conflicts over whether or not an album re-issue should go ahead, One More Love was released on 29 November 2010. The first single, titled "Who's That Chick?" featuring Rihanna was released a few weeks prior.
On 16 June 2009, The Black Eyed Peas released the Guetta-produced "I Gotta Feeling" as their second single from their fifth studio album, The E.N.D.. It became a worldwide hit topping the charts in seventeen countries. It became the most downloaded song of all-time in the United States with almost 7.5 million downloads and in the United Kingdom selling more than 1 million copies. He was nominated twice for his work with The Black Eyed Peas at the 52nd Grammy Awards; in the category Record of the Year for "I Gotta Feeling" and Album of the Year for their album The E.N.D.. In 2010, Guetta co-wrote and produced Kelly Rowland's "Commander" from her third album Here I Am. It peaked at number one on Billboard's Hot Dance Club Songs chart in the United States, and reached top ten positions in Belgium and the United Kingdom. Guetta has also co-produced "Forever and a Day", which was Kelly's next UK single from that album. Guetta also produced the singles "Acapella" and "Scream" for American singer-songwriter Kelis's fifth studio album, Flesh Tone, released on 14 May 2010. "Acapella" was released as the lead single on 23 February 2010 and topped the dance charts in the United Kingdom and United States. On 28 June 2010 American rapper Flo Rida released the single "Club Can't Handle Me" featuring Guetta. The song is included on the soundtrack album to the American 3D dance film Step Up 3D and Flo Rida's third studio album, Only One Flo (Part 1).