Pasquesi was born in Chicago and starred in the short film Regrets that premiered An Event Apart, and co-starred in I Want Someone to Eat Cheese With. He wrote for Exit 57 and Strangers with Candy, co-wrote and appeared in the Spike TV series Factory, and co-wrote and co-starred in Cop Show. In 2009, he was in the cast of Angels & Demons, where he played the character Claudio Vincenzi. He co-created and co-wrote the new show Merkin Penal. Similarly to his role of “Meat Man” in Strangers With Candy, Pasquesi plays “Knife Man” in At Home with Amy Sedaris.

The 2009 South by Southwest Film festival included the documentary Trust Us, This is All Made Up directed by Alex Karpovsky, which chronicles a “T.J. and Dave” performance. In 2009, he played a supporting role in the Harold Ramis film Year One as the Prime Minister of Sodom. Pasquesi was a cast member in the Chicago premiere of Yasmina Reza’s God of Carnage at the Goodman Theatre.