Blasberg was born in St. Louis, Missouri, to Bill Blasberg, a certified public accountant, and Carol Blasberg, the managing editor of the medical journal The Annals of Thoracic Surgery. In 2000, Blasberg graduated from Affton High School, where he was salutatorian of his class.

In 2000, Blasberg moved to New York City to attend New York University. He graduated in 2004 with honors with a dual bachelor’s degrees in dramatic literature and journalism.

From 2006 to 2010, Blasberg was the Editor at Large of Style.com, where he wrote a column called “The Blasblog.”

In 2008, Blasberg edited Influence, a fashion and art tome conceived by Mary-Kate and Ashley Olsen.

From 2009 to 2012, he wrote a column called “Fast + Louche” for Interview magazine. Blasberg co-wrote several of the New York City editions of the Louis Vuitton Travel Guides.

In April 2010, Blasberg’s debut book, Classy: Exceptional Advice for the Extremely Modern Lady, was published. It was a collection of humorous essays about etiquette and was on The New York Times best sellers list for several weeks. In October 2011, Blasberg published a follow-up to Classy called Very Classy: Even More Exceptional Advice for the Extremely Modern Lady, which was an expanded and updated version of the original.

In 2014, Blasberg worked at the Gagosian Gallery as a senior staffer. In this position, Blasberg wrote the “In Conversation” series for Gagosian Quarterly.

Before joining Vanity Fair in 2015, Blasberg was the Editor at Large of Harper’s Bazaar. Blasberg was an Editor at Large a V and VMAN. He was the founding U.S. Editor of the London-based arts publication Garage Magazine where he wrote a column called “Emails from the Edge.”

In 2015, Blasberg published Harper’s Bazaar: Models, a survey of the most important models and iconic images in fashion history, which has a foreword that was written by Karl Lagerfeld.

Starting in 2015, Blasberg hosted several Vanity Fair magazine web series, including “Conversations In The Backseat,” where he has interviewed Reese Witherspoon, Gigi Hadid, Naomi Campbell, Maria Sharapova, and Rosie Huntington-Whiteley.

Since April 2016, Blasberg has been the host of the CNN International show, CNN Style. CNN Style focuses on covering fashion internationally, but also includes art, architecture, and design. CNN Style was created 15 years after the long-running Style with Elsa Klensch.