Landing on the disabled list twice in the early part of the 2014 season, as of June 4 Mesoraco was batting .294 but had yet to amass a sufficient number of at-bats to be listed among Major League Baseball's leaders in the category. Mesoraco was named to play for the National League in the 2014 MLB All-Star Game. He finished the season with 25 home runs and 80 runs batted, playing in 114 games, leading all major league catchers in home runs and slugging percentage.
Mesoraco married his longtime fiancée, Kira, on November 15, 2014, at St. Cosmas & Damian church in Punxsutawney. They welcomed their first child, a son named Luke, on August 6, 2017.