On January 6, 2016, Mesto performed alongside Martin Garrix and Justin Mylo at Bij Igmar on SLAM!. In April, he remixed "Me, Myself & I" by G-Eazy and Bebe Rexha, officially released on April 26. The remix was followed by the bootleg of "Another You" by Armin van Buuren featuring Mr. Probz in that same month and the remix of "We're Guna Fight Em Off" by Ill Phil in June. In July, he and Justin Mylo remixed "Final Call", a single by Florian Picasso for the Remixes EP, officially released on July 8. On October 10, 2016, it was announced that Mesto signed a contract with Spinnin' Records. That same month, he released "Wiee", a collaboration with Martin Garrix on STMPD RCRDS. The single was played by Garrix as an ID at Home Festival in Treviso, Italy in early September, and was a part of his seven-track extended play Seven. He also performed at the Amsterdam Dance Event for the first time. On December 16, 2016, he released a remix of "Alone" by NERVO and Askery featuring Brielle Von Hugel, which was his first release on Spinnin' Records. A day later, he was a guest and performed at Midden In Je Weekend Show on SLAM!. He then performed at Mezz in Breda during the "3FM Clubhuis presents" and "DJs for 3FM Serious Request".