In August 2007, Bren pledged $20 million to the recently established UC Irvine School of Law. The purpose of the gift was to establish an endowment to help recruit and support a nationally recognized dean and 11 distinguished law scholars, and also to provide the dean with discretionary start-up funding. In recognition of the gift, the school was initially named the UC Irvine Donald Bren School of Law. In 2008 an agreement was reached between Bren and the University that the school would not bear his name. Erwin Chemerinsky, dean of the law school, said, "We are deeply grateful for the Bren gift, but it was decided between the chancellor and Mr. Bren that our name should be parallel to other UC schools."
In 2007, Bren made a $2.5 million commitment to the Burnham Institute for Medical Research in La Jolla, California. The contribution established The Donald Bren Presidential Chair and the money donated was used to support research conducted by the Institute such as cancer, neurodegeneration, diabetes, and childhood diseases among others.
Bren serves on the board of trustees at Caltech and the Los Angeles County Museum of Art. He was elected a Fellow with the American Academy of Arts & Sciences in 2007 in the category of Business, Corporate and Philanthropic Leadership.