In 2008, Nhi independently released her first single, “Khóc” (Cry). The song became a minor hit, which helped her to gain some recognition and get signed to Tinu Production Company. She began to make teen-pop songs, which gave her more recognition. She also starred in a few movies and films such as Giải cứu thần chết, Thứ ba học trò, and Công chúa teen và ngũ hổ tướng.

On April 19, 2008, Nhi’s fanbase was established under the name Potatoes (shortened as Po) which is still active. Her fan club helped her win the BFF contest and become the first Vietnamese singer to own “a star”.

Nhi announced her hiatus in 2009. During her hiatus, it was rumored that she was pregnant, but she said it was only a rumor. She came back with her official debut album, The First Step, which won the Favorite Album Award at the HTV Awards. The album also reached the top 10 at the Zing Music Awards. The same year, her song “Từng Thuộc Về Nhau” became a big hit and received positive reviews.

In September 2011, Nhi released her EP The Singer, a collaboration with many Vietnamese popular musicians. She won Best Female Singer at the Zing Music Awards, and The Singer was ranked in the Top 10 Album of the Year.

In early 2012, she voiced over in The Lorax with TV host Thanh Bach. At the end of April, Nhi debuted her music video for “Sau Mỗi Giấc Mơ”, in which 80% of scenes were underwater. The song and music video topped many Vietnamese music charts; subsequently, Nhi won Favorite Female Singer at the Zing Music Awards. At the end of 2012, she held a mini concert with the Bo tu hoan hao cast. In 2013, her MV for “Tìm Về” was the first in Vietnam that featured 3D scenes and technology.

In early 2013, she hosted Dancing with the Stars. She also stopped working with her manager Dang Phuong and signed with Ong Cao Thang’s 6th Sense Entertainment. Due to her changed image, she had a breakthrough with EDM. Along with this success, she still gained successes for her pop songs, namely “Tim Về” and “Xoa”. She won several awards and started to build a fanbase; she sponsored many brands.

In 2014, Nhi released her second album I Wanna Dance, featuring pop-electronic songs. The album’s lead single, “I Wanna Dance”, topped many music charts in Vietnam, as well as Chinese and Spanish charts. The song won Favorite Pop – Electronic Song at the Zing Music Awards 2014. Nhi also won Favorite Female Singer for the fourth time. At the 19th Golden Apricot Blossom Awards, she won Favorite Ballad Singer. In September, she was confirmed to be a judge on Vo Chong Minh Hat.

On March 28, 2015, she was the official judge of the Toa Sang Tai Nang Chau A contest, along with Midu and Lam Vinh Ha. On April 5, 2015, Nhi won Favorite Female Singer at the HTV Awards.

In early February, at the 20th Golden Apricot Blossom Awards, she won Favorite Ballad Singer. In early 2015, she competed in the first season of The Remix, which she won on May 3. Here, she also performed her single “Stop Loving You”, which immediately topped many music charts.

On May 16, she was a judge on Ngoi Sao Phuong Nam. On May 31, 2015, she came back to Vietnam Idol as a guest, in which she performed “Hot” at the first night gala.

On January 22, 2016, at the 21st Golden Apricot Blossom Awards, she won Favorite Ballad Female Singer for the third consecutive time and Top 10 Artists of the Year. On January 25, she was enlisted in the 30 Under 30 list by Forbes Vietnam under her real name.

In the fourth season of The Voice Kids of Vietnam, Nhi coached alongside her boyfriend Ông Cao Thắng. On October 2, Nhi had her first live show in eight years, called It’s Showtime – Dệt Giấc Mơ Bay. On October 8, Nhi won Best Vietnamese Female Artist from the Big Apple Music Awards 2016. On November 6, 2016, she won Best Asian Artist at the 2016 MTV EMAs.

On January 3, 2017, Nhi was a coach on the fourth season of The Voice of Vietnam, alongside Thu Minh, Tóc Tiên, and Noo Phước Thịnh. During the same month, Nhi won Artist of the Year at the Yan Vpop 20 Awards, as well as Favorite Female Artist at the Zing Music Awards for the sixth time.

On October 4, 2018, Nhi performed at the 2nd ASEAN – Japan Music Festival 2018, representing Vietnam. She remixed the song “Nụ cười Việt Nam” and performed “Xin lỗi anh quá phiền”. For her third studio album, Ten On Ten, Nhi released the music videos for singles “Giả vờ say” and “Gọi em đi”. On December 9, the album was released and topped the Vietnamese iTunes chart.

In November 2019, she got married with Dong Cao Thang in an emotional wedding with a great number of public figures.