In 2003, he opened his own practice in Bal Harbour, Florida, and six years later moved to a new five story building there. He told a reporter for Miami New Times in 2012, that “Marketing makes the world go ’round” and that he had courted the publicity of controversy.

Salzhauer authored a children’s book in 2008, titled My Beautiful Mommy which focused on a young girl whose mother undergoes a tummy tuck, a nose job, and breast augmentation. It was illustrated by Victor Guiza. Salzhauer and the book were criticized for promoting elective cosmetic surgery and for a line that suggests that mommy’s new nose will “be prettier.” Child psychologist Elizabeth Berger has noted that while an explanatory book will be helpful for children, it “can be difficult for small kids to understand”. Salzhauer defended the book, saying that he wrote it to help parents explain such surgeries to their children.

In 2009, Salzhauer published a virtual plastic surgery iPhone application that allowed users to tweak photographs of themselves to simulate operations. The New York Times commented that the results were “worthy of a fun-house mirror”.

In 2012, he caused controversy within the Orthodox Jewish community after producing a video titled “Jewcan Sam” with the Jewish punk band The Groggers. The video features a young Jewish man who undergoes rhinoplasty at the request of his girlfriend. The American Society of Plastic Surgeons initiated an ethics investigation as a result, and both Salzhauer and the band were accused of playing into Jewish stereotypes.

Beginning in 2012, Dr. Miami began making news headlines for working with several reality television stars. He has been known for performing several plastic surgery procedures on cast members of shows such as Teen Mom, Teen Mom 2, Love & Hip Hop: New York, Black Ink Crew, and Bad Girls Club. Past reality television patients have been Farrah Abraham, Kailyn Lowry, Briana DeJesus, Mariahlynn, JaKeita “Sky” Days, Raquel “Rocky” Santiago, Stephanie “Steph” Rivera, Danielle “Danni” Victor, Gabrielle “Gabi” Victor, Suha “Susu” Ibrahim, and Hanan Ibrahim.

In January 2016, Salzhauer was nominated for the eighth annual Shorty Award in the Snapchatter of the year category. He came in second place, losing to DJ Khaled.

In July 2016, WE tv announced a reality television series, Dr. Miami, starring Salzhauer. The series premiered on March 31, 2017 and ran for 6 episodes on WE tv.

In 2017, Salzhauer and recording artist Adam Barta released a song called “Flawless”. The song reached #24 on the Billboard dance/electronic digital chart, #9 on iTunes dance singles chart, and #32 on the Billboard hot club dance chart/