Scott joined his brothers in Las Vegas in 2010 and purchased a condo on "The Strip," a highly concentrated urban area just south of Las Vegas. However, he and Jonathan purchased a joint home in 2011. Its renovation became the subject of the twins’ fourth TV series, Property Brothers: At Home, and aired on HGTV in the United States, as well as on the W Network in Canada. It became the most highly rated HGTV series premiere since 2009. After the success of Property Brothers at Home, Scott Brothers Entertainment went on to create another spin-off series called Property Brothers: At Home on the Ranch, where the brothers went back to their old stomping grounds of Alberta, Canada to accomplish a 10-week renovation for a family friend’s Rocky Mountain estate. As part of the show, Drew and Jonathan wrote and recorded two country singles that premiered during the third and fourth episode of the series. The singles "Hold On" and "Let the Night Shine In" were released on various music platforms, including iTunes, Amazon.com and Google Play. Both songs were co-written by the brothers along with Nashville songwriters Victoria Shaw and Chad Carlson. "Hold On" hit number 38 on Billboard's Hot Country Songs chart and was accompanied by a music video that has more than three million Vevo views. The Scott Brothers released a third song, "My House," featuring Eric Paslay, on January 12, 2017. Filmed at the brothers' Las Vegas home, the song's music video depicts a racous house party, and includes cameos by Carrot Top, RaeLynn and Lindsay Ell. All proceeds from "My House" single sales have been donated to St. Jude Children's Research Hospital.
In 2010, Drew and Jonathan created Scott Brothers Entertainment, an independent production company. In 2013, they shifted the focus from film to creating original content for television and digital platforms. Their web series Toddler vs. Toddler was produced in 2013 and aired on HGTV and W Network.com. The short Makeover Manor was produced for Funny or Die and also starred several reality stars famous in improvement:—Love it or List It" stars David Visentin and Hilary Farr, Scott McGillivray, Ty Pennington, Bryan Baeumler, Candice Olson, and Sandra Rinomato—plus Jersey Shore stars, Sammi Giancola and Ronnie Ortiz-Magro. Scott Brothers Entertainment also produced seasons three and four of Brother Vs. Brother, the series Half Price Paradise for HGTV and HGTV Canada, as well as Property Brothers: At Home. Drew has written a docu-series based on current social topics that he is passionate about, including solar power. The show has a planned release of 2018.
Drew met his wife, Linda Phan, at a Toronto Fashion Week event in 2010. Beginning in 2014, they lived together in the Las Vegas home that Drew still owns with his twin. He estimated they were only there about twice a year, however, as Phan travels with Scott as Creative Director of Scott Brothers Entertainment, "overseeing their digital content, product and merchandise lines, and marketing campaigns." Scott has said that he and Phan are "workaholics," and that "getting out of the home office is step one for a great date." They became engaged on December 13, 2016, and were wed in a destination wedding in Italy on May 12, 2018. The ceremony incorporated elements of their respective Scottish and Chinese heritages, and was the subject of a show called Drew and Linda Say I Do, which aired on June 2, 2018 on TLC. Drew co-wrote (along with Victoria Shaw and Chad Carlson) and performed a song for his bride called "You Chose Me," and an accompanying music video was released to YouTube on June 2, 2018. They have also expressed their desire to have children. In October 2017, they moved to Los Angeles, California, and the couple has said they plan to raise their future children there.