Dustin played high school football at Jefferson High School in Lafayette, Indiana. While at Jefferson, Dustin was a three-sport standout in football, basketball, and track. During his senior year at Lafayette Jefferson High School he was the state’s leading wide receiver in football with 114 receptions in 2002, was second team All-State as a small forward in basketball, and he was the high jump state champion in Indiana, clearing 6 ft 9 in in a steady rain after coming second to the Philadelphia 76ers’ Rodney Carney with a jump of 6’10”. Keller was named one of top 50 receivers in nation by Street & Smith’s and first-team all-state as senior after setting state records with 113 receptions and 1,804 yards (16.0 average) with 22 touchdowns. He was a finalist for Mr. Football.

Keller was drafted by the New York Jets 30th overall in the 2008 NFL Draft. On July 18, 2008, he signed a 5-year 12 million dollar contract with the Jets. Keller was slowly phased into the offense alongside the veteran quarterback Brett Favre. Keller finished a strong rookie season with 48 receptions, 535 yards and 3 touchdowns.

Keller led the Jets in receptions (55) in 2010. In 2011, he again led the Jets in receptions (65) for 815 yards and 5 touchdowns.

After not missing a game or a practice in his first four years in the NFL, a pulled groin and high ankle sprain hindered Keller’s production in the 2012 regular season, limiting him to 28 receptions for 317 yards and two touchdowns in only 8 games.

Keller signed with the Miami Dolphins on March 15, 2013. On August 17, 2013, Keller suffered a career-ending knee injury in a preseason game against the Texans, tearing his ACL, MCL, and PCL, and also dislocating his knee. On August 20, 2013, the Dolphins placed Keller on injured reserve.