Pedroia achieved his first multi-home run game on September 9, 2009, against the Orioles.
On January 9, 2009, Pedroia was named as the cover athlete of the baseball video game MLB 09: The Show, and appeared in several commercials for the game.
In August 2009, Pedroia's wife, Kelli, gave birth to the couple's first child, a boy named Dylan. In September 2012, Pedroia's wife Kelli had a second son, Cole. On June 2014, the couple had their third son, Brooks. Pedroia is the nephew of Carolina Panthers defensive coordinator Phil Snow.
In a 2009 interview given to Boston magazine, Pedroia criticized his home town of Woodland, California, calling it a "dump" and a city that never embraced him. This generated backlash from his hometown and his family received death threats. Pedroia later clarified his comments saying he was only joking and his comments were taken out of context. The original article's author, however, insisted that his use of the comment was not misleading. His transcript of the interview quoted Pedroia as saying "It's a dump. You can quote me on that. I don't give a shit."