Between 1955 and 1964, he presented the long-running Sports Report on the BBC Light Programme. In 1965, he left the BBC to join the ITV contractor ABC, where he pioneered the chat show format in the UK. He hosted The Eamonn Andrews Show on ITV for five years. He was known for coming up with off-the-cuff linkings that did not work, such as: "Speaking of cheese sandwiches, have you come far?" This was parodied by the character Seamus Android on Round the Horne in the 1960s, performed by Bill Pertwee. In the 1960s and 1970s he presented Thames Television's Today news magazine programme.
He was probably best known as the presenter of the UK version of This Is Your Life, between its inception in 1955 and his death in 1987, when he was succeeded by Michael Aspel (who had also succeeded Andrews as the host of Crackerjack! more than twenty years earlier). Andrews was the first This Is Your Life subject on British television when he was surprised by the show's creator, Ralph Edwards. Andrews also created a long-running panel game called Whose Baby? that originally ran on the BBC and later on ITV. He was a regular presenter of the early Miss World pageants.