Andrews was born in Synge Street, Dublin, and educated at Synge Street CBS. He began his career as a clerk in an insurance office. He was a keen amateur boxer and won the Irish junior middleweight title in 1944.

By 1944 he was the Hon. Secretary of St. Andrew’s Boxing Club. In 1946 he became a full-time freelance sports commentator, working for Radio Éireann, Ireland’s state broadcaster. In 1950, he began presenting programmes for the BBC, being particularly well known for boxing commentaries, and soon became one of television’s most popular presenters. The following year, the game show What’s My Line? began and Andrews was the host. He was also an occasional panellist and host of the original American version.

Andrews married Gráinne in 1951. They raised three adopted children.

Between 1955 and 1964, he presented the long-running Sports Report on the BBC Light Programme. In 1965, he left the BBC to join the ITV contractor ABC, where he pioneered the chat show format in the UK. He hosted The Eamonn Andrews Show on ITV for five years. He was known for coming up with off-the-cuff linkings that did not work, such as: “Speaking of cheese sandwiches, have you come far?” This was parodied by the character Seamus Android on Round the Horne in the 1960s, performed by Bill Pertwee. In the 1960s and 1970s he presented Thames Television’s Today news magazine programme.

He was probably best known as the presenter of the UK version of This Is Your Life, between its inception in 1955 and his death in 1987, when he was succeeded by Michael Aspel (who had also succeeded Andrews as the host of Crackerjack! more than twenty years earlier). Andrews was the first This Is Your Life subject on British television when he was surprised by the show’s creator, Ralph Edwards. Andrews also created a long-running panel game called Whose Baby? that originally ran on the BBC and later on ITV. He was a regular presenter of the early Miss World pageants.

Throughout the 1950s, he commentated on the major British heavyweight fights on the BBC Light Programme, with inter-round summaries by W. Barrington Dalby. On 20 January 1956, he reached No 18 in the UK Singles Chart with a “spoken narrative” recording named “The Shifting Whispering Sands (Parts 1 & 2)”, which was produced by George Martin with musical backing by the Ron Goodwin Orchestra, released by Parlophone as catalogue number R 4106, a double-sided 78 rpm record. The song later reappeared on Kenny Everett’s compilation album The World’s Worst Record Show, which was released in June 1978.

For his work in British broadcasting Andrews was awarded an honorary Commander of the Most Excellent Order of the British Empire in 1970.

After months of illness during 1987, originally caused by a virus contracted during a plane journey, Andrews died from heart failure on 5 November 1987 aged 64 at the Cromwell Hospital in London.

He had recorded his last edition of This Is Your Life six days previously on 30 October 1987. After his death, the show, and two others that had yet to be broadcast, were postponed until, with his widow’s permission, they were broadcast in January 1988.