In 2008, Williams provided legal counsel in family law and civil litigation. She was a public defender and returned to private practice in 2010. Williams provided representation for clients in homicide, rape, drug, sex crime, and federal offense cases. She was a correspondent for CBS News and a contributor for Fox News, with appearances on Hannity and The O’Reilly Factor, and has appeared as a co-host on Outnumbered and The Five. Williams was a co-host for the Fox News Specialists afternoon show that first aired May 1, 2017, with co-hosts Eric Bolling and Katherine Timpf. The show was created after the departure of Bill O’Reilly to rebuild the Fox News Channel lineup. Fox News Specialists was cancelled on September 8, 2017, after Eric Bolling departed from the network amid sexual harassment allegations.

On June 5, 2017, Williams joined WABC Radio as co-host of a noon-to-3 p.m. talk show along with long-time radio personality Curtis Sliwa, replacing Ron Kuby as Sliwa’s co-host on the show. Her last show aired October 18, 2017.

On October 8, 2020 it was announced that she would be joining the cast of The Real Housewives of New York City for its thirteenth season, becoming the show’s first African-American cast member and the second attorney to join the franchise after Aviva Drescher who was a cast member from seasons 5 to 6.