It was also about this time that Varèse began work on his first composition in the United States, Amériques, which was finished in 1921 but would remain unperformed until 1926, when it was premiered by the Philadelphia Orchestra, conducted by Leopold Stokowski (who had already performed Hyperprism in 1924 and would premiere Arcana in 1927). Virtually all the works he had written in Europe were either lost or destroyed in a Berlin warehouse fire, so in the U.S. he was starting again from scratch. The only surviving work from his early period appears to be the song Un grand sommeil noir, a setting of Paul Verlaine. (He still retained Bourgogne, but destroyed the score in a fit of depression many years later.)
At the completion of this work, Varèse, along with Carlos Salzedo, founded the International Composers' Guild, dedicated to the performances of new compositions of both American and European composers. The ICG's manifesto in July 1921 included the statement, "[t]he present day composers refuse to die. They have realised the necessity of banding together and fighting for the right of each individual to secure a fair and free presentation of his work." In 1922, Varèse visited Berlin where he founded a similar German organisation with Busoni.