Verástegui was born in Xicoténcatl, Tamaulipas, Mexico. He was raised in a practicing Catholic family. After finding success as a musical entertainer, and then as a soap opera star, he decided to pursue a career in Hollywood. In 2002, before filming commenced on Chasing Papi, Verástegui took voice-coaching lessons to improve his English pronunciation. The coach was a committed Catholic, and in the course of their conversations Verástegui re-discovered his faith and resolved to change his lifestyle. He also declared that he had decided to turn down offers to play roles in films that conflicted with his Catholic beliefs or that insulted his Latino brethren. In an interview with Dave Hartline, the author of The Tide Is Turning Toward Catholicism and published by Catholic Report, he said he was committed to attend Mass daily, praying, reading the Bible, saying the rosary and going to Confession at least once a week. He also said that he first encountered his renewed faith in Scott Hahn’s book, Rome Sweet Home that “had a great impact on me and its influences can be seen in a lot of what I do”.

In 2008, he released a long video message denouncing the high rate of abortion in Hispanic communities in the United States and speaking out loudly about alleged targeting of the Hispanic communities with messages supporting abortion by the Barack Obama campaign during the presidential race.

On September 15, 2020 President Donald J. Trump announces his intent to nominate and appoint Eduardo Verastegui, to be a member of the President’s Advisory Commission on Hispanic Prosperity.