She left the show three times. The first time was for several months in 1963, when she was replaced in the role of Lisa by actress Pamela King. She left again in 1965 to bring her Lisa character to her own prime time soap spin-off, Our Private World. Our Private World lasted less than a season, and Fulton took several months off before returning to As the World Turns in early 1966 . She left again in 1983 after a contract dispute with executive producer Mary-Ellis Bunim, returning the next year. During Fulton’s 1983-1984 absence, the role of Lisa was played by Betsy von Furstenberg. She was also temporarily replaced for a few days by Carmen Duncan in 2004, when she could not appear in several episodes due to illness.

While playing Lisa, Fulton performed in the Off-Broadway production of The Fantasticks and the Broadway production of Who’s Afraid of Virginia Woolf? as “Honey” in 1963. Fulton would perform her scenes for the live airing of As the World Turns, then be on a Broadway stage for the matinee performance in Who’s Afraid of Virginia Woolf? (in a 2007 Archives of American Television interview, Fulton explained that there was only a 30-minute window, between the time ATWT concluded its live broadcast at 2:00 p.m, and the beginning of the first act of Virginia Woolf, for her to travel from CBS’ studios to the Billy Rose Theatre, and get into costume, and that this was only possible because her character didn’t appear onstage for the first twenty minutes of the play), and by evening she would be back onstage in the Off-Broadway musical, The Fantasticks. Her other theatre credits include the Off-Broadway production of Abe Lincoln in Illinois with Hal Holbrook in 1963, Many Loves, Summer of the Seventeenth Doll, and Nite Club Confidential.

Fulton’s portrayal of Lisa created the strongest prototype of its time for the daytime vixen. The character and actress were, in Fulton’s first decades on As the World Turns, very popular (to the point where, in the late 1960s, Fulton had to hire a publicist, the first soap actress to do so). The character became hated after a simple sequence where Lisa hires a maid to clean the house and went gallivanting about town. When mother-in-law Nancy complimented Lisa on what a nice home she made for her son Bob, the audience became furious, stopping Fulton on the street and slapping her. CBS had to hire a bodyguard to escort her to and from the studio. Despite her popularity, Fulton’s run has not been without controversy. During the late 1960s, after her onscreen son was aged from age 12 to 19, Fulton insisted it be written into her contract that her character could not become a grandmother. She feared that the perception of her as a grandmother, instead of a glamorous and vital woman, would cause the writers to kill off her character. (This had been done when Barbara Berjer, who was playing one of Lisa’s rivals, Claire Shea, became a grandmother.) Fans, believing that the “granny clause” as it became known, was still in effect (which it was not), sent Fulton so much threatening “hate mail” when Lisa’s onscreen daughter-in-law, Margo, had a miscarriage in 1986, that she had to hire a bodyguard.

Fulton was married to landscape architect Rick McMorrow for three months in 1989.

In September 1998 she was inducted into the Soap Opera Hall of Fame. Fulton has also appeared in five independent films which earned her the Achievement in Television and Film Award at the Independent Filmmakers Award ceremony. In 2003, she was presented with the Lifetime Achievement Award by the TV Academy during the 31st Annual Daytime Emmy Awards.

Fulton is a 1956 graduate of Greensboro College and was granted an honorary doctorate in 2005, on the 50th anniversary of her college graduation. She was the commencement speaker at Greensboro College’s graduation ceremony in 2005.

Fulton was prominently featured in a May 2000 show marking her and costar Don Hastings’ fortieth anniversaries on ATWT, as well as in April 2006 during the show’s 50th anniversary episode; and from January 2008 to August 2008, was seen in at least two episodes per week. Her appearances dropped off after that time, though she was again featured in a two-part tribute episode in May 2010, celebrating her fiftieth year on the show; she remained on the show through its cancellation, appearing in the final episode in September 2010.