On 3 January 2014, the Netherlands Ministry of Security and Justice and the Mexican Embassy in the country confirmed that a 33-year-old Mexican citizen had been arrested by the Dutch police as he arrived from Latin America to Amsterdam Airport Schiphol in the Netherlands using a false name on 30 December 2013. Initially, the authorities did not give any details on the identity of the detainee, but an anonymous U.S. federal agent and Mexican local newspapers leaked information to the media that the man was in fact Aréchiga Gamboa. The arrest of the drug lord was officially confirmed later that day by the U.S. government. According to officials, Aréchiga Gamboa travelled with the fake name of Norberto Sicairos García; at the time of his arrest, he was carrying an iPhone 5, a Blackberry Bold, three airplane tickets, credit cards from Visa and MasterCard from Banamex, and a Mexican driver's license. Upon his arrest, he was sent to the Vught maximum-security prison. U.S. law enforcement managed to identify Aréchiga Gamboa through unspecified forensic methods despite the fact that the drug lord had used a fake name to travel, undergone plastic surgery to change his appearance, and altered his finger prints.
On 2 January 2014, he appeared before a judge, who spoke about his situation and the motives behind his arrest. The Dutch authorities confirmed that the drug lord had been arrested at the request of the U.S. government, which had contacted Interpol to assist them in the arrest of the drug lord for charges relating to drug trafficking. They did not contact Mexican officials. The following day, the U.S. District Court for the Southern District of California solicited an extradition request to bring the drug lord to trial in the U.S.
On 8 January 2014, the U.S. Department of the Treasury sanctioned the drug lord under the Foreign Narcotics Kingpin Designation Act (Kingpin Act), which froze assets he may have had in the U.S. and virtually prohibited U.S. citizens from carrying out financial or commercial deals with him. The document alleged that, besides working for the drug lord "El Mayo" Zambada, Aréchiga Gamboa coordinated logistics and drug transportations for "El Chapo" Guzmán and worked alongside Gonzalo Inzunza Inzunza (alias "El Macho Prieto"), another Sinaloa Cartel high-ranking enforcer who was killed in Sonora in December 2013. The drug lords he worked for had already been sanctioned by the U.S. government under the Kingpin Act in 2001, 2002, 2009, and 2011.
On 14 May 2014, an official spokesperson of a court in Haarlem stated to the press that the request of the U.S. to extradite Aréchiga Gamboa was planned to be defined by 29 May 2014. On 28 May 2014, a Dutch court approved the extradition to the U.S. The defense of El Chino Ántrax, who was not present during the hearing, was allowed by law to appeal the decision, a process that could have taken months. On 10 July 2014, he was extradited from Amsterdam to the U.S., where he arrived at the San Diego International Airport at around 2:00 p.m. under tight security by the DEA and the U.S. Marshal Service. Upon his arrival, he was taken into custody and booked for his drug-related charges. He was expected to be arraigned on such charges the next day.
The following day, he pleaded not guilty to the drug charges against him and was held without bail after the U.S. Magistrate Mitchell D. Dembin deemed him a public threat and capable of fleeing to Mexico if released. Those present in the courtroom had to pass a secondary metal detector and pat-down before entering the hearing site. According to one of the case's attorneys, a group of women who were supposedly family members of Aréchiga Gamboa sat in one of the middle rows of the courtroom. They declined to comment about the case, just like Aréchiga Gamboa's defense Frank Ragen. After his court appearance, Aréchiga Gamboa was imprisoned at the Metropolitan Correctional Center, San Diego and was scheduled to appear in court again for a motion hearing conducted by federal judge Dana Makoto Sabraw on 22 August 2014.
His romantic partner Yuriana Castillo Torres was reportedly kidnapped by armed men while heading to her vehicle after leaving a gym in Culiacán, Sinaloa on 6 May 2014 Her corpse was discovered on 06:45 the next day by Mexican law enforcement at a vacant lot in Lomas de Guadalupe neighborhood in Culiacán, and confirmed to be hers by her family members at the forensic installations. Post-mortem reports showed that Castillo Torres had been tortured, received several blows to the head, and that her hands and legs were tied with an electric cable. At the funeral home where the wake took place, members of Los Ántrax reportedly paid their condolences by leaving a floral ornament in honor of her.