In 2006, Estrada was a finalist in the Philippine television vocal competition, Pinoy Pop Superstar. In 2007, she won the 2007 Beat Music Awards, and earned a record and management contract with RockSTAR Music Corporation. Her debut single, “Insatiable”, was released in May 2007 and went to no. 1 on the Canadian Top 40 Charts. Between 2008 and 2009 and later on July 1, 2011, Estrada performed at the Canada Day Festival in Surrey, B.C.

In August 2009, Estrada’s Canadian television series, Love Court debuted on MuchMusic which featured her song “First Degree” as its theme. “Love Court” was played many times each week and was later seen on MuchMoreMusic.

My Date with…Elise Estrada in Thailand aired on MuchMusic on September 8, 2010.

Here Kitty Kittee, Estrada’s second album was scheduled to be released on November 9, 2010, on iTunes Canada according to her Entertainment Tonight Canada interview. The album’s first single “You’re So Hollywood” was released on July 9, 2010, and the music video was premiered at Muchmusic New Music Videos on September 23, 2010. Her second single, “Lipstick”, previewed on her Myspace page. The music video for the song was filmed in London and was finalized and premiered on Estrada’s Vevo Channel on December 1, 2010. Estrada starred and sang as a guest on CW Network’s Hellcats episode “God Must Have My Fortune Laid Away” on February 15, 2011. She sang a new song called “I Be That”.

Estrada began working on her third studio album titled #Round 3 in 2012. On October 2, 2012, the single “Piece of Me”, a dance-pop/bubblegum pop track, was released. It was followed by another single on October 23 titled “Wonder Woman”, which was dedicated to Amanda Todd who committed suicide from cyber-bullying. On January 7, 2014, she released the album’s lead single, “U Don’t Need 2 Know”. Its music video premiered on VEVO on the same day. #Round 3 was eventually released on July 29, 2014. She also signed a record deal with VIVA Records to release the album in Asia and handle her promotions in the Philippines during her concert tours from August to September.

In December 2019, Estrada got engaged to boyfriend of ten years, Adam Hurstfield. Estrada announced that she was pregnant with her first child in 2020.