After leaving school at the age of 16, Elizabeth traveled to London to spend time with her Holland cousins. She also spent some time in Newcastle upon Tyne (with the Rev William Turner's family) and from there made the journey to Edinburgh. Her stepmother's brother was the miniature artist William John Thomson, who in 1832 painted a portrait of Elizabeth Gaskell in Manchester. A bust was sculpted by David Dunbar at the same time.
On 30 August 1832 Elizabeth married a Unitarian minister, William Gaskell, in Knutsford. They spent their honeymoon in North Wales, staying with her uncle, Samuel Holland, near Porthmadog. The Gaskells then settled in Manchester, where William was the minister at Cross Street Unitarian Chapel. Manchester's industrial surroundings influenced Elizabeth's writing in the industrial genre. Their first child, a daughter, was stillborn in 1833. Their other children were Marianne (1834), Margaret Emily, known as Meta (1837), Florence Elizabeth (1842), and Julia Bradford (1846). Marianne and Meta boarded at the private school conducted by Rachel Martineau, sister of Harriet, a close friend of Elizabeth. Florence married Charles Crompton, a barrister and Liberal politician, in 1863.