In 1903 Butterfield was accepted into the architecture program at Syracuse University in New York. After graduation, in 1907 she became the first licensed woman architect in the state of Michigan. With her father, in 1917 she established the firm of Butterfield and Butterfield. The firm specialized in church architecture. It led the transformation of churches, especially Methodist, from Sunday meeting halls to centers of daily community and social activities. She practiced architecture in Detroit and Pontiac, designing 26 churches throughout the state. Her other projects included factories, summer camps, stores, schools, and homes.