Inciarte signed as an international free agent with the Diamondbacks on May 25, 2008, and began his career in the Rookie-class affiliates in 2008 and 2009. He has played in Arizona’s minor league affiliates since the 2008 season, including the Yakima Bears in 2010. He hit .307 with two home runs, 47 runs batted in, and 28 stolen bases in Class-A for the South Bend Silver Hawks as well as Class-A Advanced for the Visalia Rawhide.

The Philadelphia Phillies selected Inciarte from the Diamondbacks with the 15th pick in the 2012 Rule 5 draft. He competed for a spot with the Phillies as a backup outfielder during spring training, and ultimately made their 2013 Opening Day roster. He remained with the Phillies for only one game (in which he did not appear), however, as he was designated for assignment following the team’s acquisition of Ezequiel Carrera on April 2. The Diamondbacks reclaimed Inciarte from the Phillies on April 4, and assigned him to the Mobile BayBears of the Class AA Southern League. With Mobile, Inciarte had a .281 batting average, five home runs, 17 doubles, 25 runs batted in, and 43 stolen bases. He appeared in the Southern League All-Star Game. After the season, the Diamondbacks added Inciarte to their 40-man roster.

Inciarte began the 2014 season with the Reno Aces of the Class AAA Pacific Coast League. He batted .312 with two home runs and seven stolen bases in 109 at-bats before he was promoted to the major leagues. He made his major league debut on May 2, 2014, and recorded a hit in his first major league game. He hit his first major league home run on July 5 off of Aaron Harang of the Atlanta Braves. Inciarte batted .303 with 21 stolen bases for the Diamondbacks in 2015. After the 2015 season, Inciarte won the Fielding Bible Award for players who played multiple positions.

On December 9, 2015, the Diamondbacks traded Inciarte, Dansby Swanson, and Aaron Blair to the Braves for Shelby Miller, and Gabe Speier. Inciarte started for the Braves as their center fielder and leadoff hitter on Opening Day. The Braves placed Inciarte on the disabled list on April 11. He was reactivated on May 6. The time he missed negatively impacted Inciarte’s offensive production, as he recorded a .227 batting average in the first half of the season. After the All-Star break, Inciarte’s hitting improved. He finished the year with a .291 batting average, coupled with three career-best marks, a .351 on-base percentage, a .381 slugging percentage, 85 runs scored, and seven triples. In 131 games, Inciarte also stole 16 bases. Though he finished behind Billy Hamilton in defensive Wins Above Replacement (as tabulated by Fangraphs), Ultimate Zone Rating, and Defensive Runs Saved, Inciarte won the 2016 National League Gold Glove for center fielders due to his superior arm strength and accuracy. On December 23, 2016, the Atlanta Braves announced that Inciarte had been signed to a five-year extension worth approximately $30 million.

On April 14, 2017, Inciarte recorded the first defensive out, first hit, and first home run at the Braves’ new venue, SunTrust Park. The Braves won 5-2 over the San Diego Padres. On May 22, 2017, Inciarte recorded his first career five-hit game against the Pittsburgh Pirates in a 5-2 Braves victory. Weeks later, on June 4, 2017, Inciarte recorded his second five-hit performance, as well as his first 5-RBI game in a 13-8 win against the Cincinnati Reds. He was the only Brave selected to the 2017 Major League Baseball All-Star Game. Inciarte recorded his first 200-hit season on September 26, with a double in the first inning against the New York Mets. At the end of the year, Inciarte won the National League Rawlings Gold Glove Award for center fielders for the second time in his career.

Inciarte’s father, Astolfo, played baseball in Venezuela. His brother, also named Astolfo, played in the minor leagues for the Diamondbacks organization, until their father died and he returned home to take over the family business. He is also a Real Madrid football club supporter. Inciarte played in the 2017 World Baseball Classic, representing his native country of Venezuela.

In 2018, Inciarte’s defense in center field continued to impress en route to his third consecutive Gold Glove award. He hit .265/.325/.380 with ten home runs, 61 RBIs, and 28 stolen bases.

In 2019, injuries to his torso and hamstring limited Inciarte to 65 games. He hit .246/.343/.397 with 5 home runs and 24 RBIs in 199 at bats.

In 2020 he batted .190/.262/.250 with 17 runs, one home run, and 10 RBIs in 116 at bats. He had the lowest average exit velocity of any major league batter, at 78.2 mph, and the lowest percentage of hard hit balls, at 6.4%.