Born in Rome, his family moved to Switzerland in 1977. He graduated from Babson College in 1989, and earned an MBA at Harvard Business School in 1993.

Bertarelli met Kirsty Roper, a former 1988 Miss UK and songwriter, while on holiday in Italy in 1997. The couple married in 2000, and have three children. The couple live in Gstaad and also spend time in their house on the shores of Lake Geneva.

Bertarelli and his family established a foundation in 1999 for promoting research and development in the field of male and female infertility, assisted reproduction technologies, andrology, genetics and endocrinology; supporting training, education and international and national exchanges in these areas through grants. The Bertarelli Foundation, in Trelex, Switzerland, merged into the Foundation FABER, in Lausanne, in 2006, and since 2008 a renewed Bertarelli Foundation has regrouped the family’s numerous philanthropic initiatives in the fields of charity, health, sciences, sport and culture.

In 2000, Bertarelli founded the yachting syndicate Team Alinghi, which in 2003, representing the Société Nautique de Genève, won the Louis Vuitton Cup before beating Team New Zealand in Auckland to win the America’s Cup. It was the first time a team had ever won the coveted sailing trophy on its first attempt, with the victory bringing the Cup to Europe for the first time. Team Alinghi hired sailors from many different nationalities, including Russell Coutts and Brad Butterworth, respectively skipper and tactician of Team New Zealand’s 2000 crew. Bertarelli was Team Alinghi’s only Swiss national serving as navigator in 2003 and subsequently as an afterguard runner and grinder in 2007, when Team Alinghi defended the America’s Cup in Valencia. On July 3, 2007, Alinghi beat Team New Zealand in race 7 by 1 second to retain the America’s Cup, winning the series 5-2.

Between 2002 and 2009, Bertarelli served as a board director of UBS AG. Management of the family’s wealth is mainly through the Waypoint Capital group, which invests through its owned-businesses that are active in asset management, including real estate, and healthcare. These businesses include Kedge Capital, an investment management group specialising in hedge funds, private equity and real estate; Northill Capital, an asset management business; a UK real estate investment fund, Crosstree; and Gurnet Point Capital, a fund based in Boston that invests in healthcare and life science business.

In recognition of his success, in 2003 Bertarelli was named Chevalier de la Légion d’honneur by French President Jacques Chirac, and was given the Cavaliere di Gran Croce by Carlo Azeglio Ciampi, President of the Italian Republic.

Bertarelli and his family sold the company to Merck KGaA of Germany in January 2007 for US$13.3 billion, forming the new company Merck-Serono. His family split an estimated $9 billion stake at that time, which added to previous share sales when the company floated on the NY stock market in 2000, which is now invested mainly through his Waypoint Capital investment vehicle. Bertarelli currently co-chairs – with his sister Dona – the Bertarelli Foundation which focuses on marine conservation and neuroscience research.

In December 2008, Appledore Shipbuilders launched the hull of Project55, Bertarelli’s new yacht, which was completed as Vava II by Devonport Engineering Consortium Ltd at Plymouth in February 2012

Société Nautique de Genève and Bertarelli’s efforts to organize the 33rd America’s Cup following their 2007 victory in Alinghi were subject to numerous legal challenges by the Golden Gate Yacht Club. The race finally took place in February 2010, in Valencia, Spain. Bertarelli was the primary helmsman of his boat Alinghi 5, which lost both races against the challenger USA 17 by a considerable margin.

On 22 May 2013, it was announced that a consortium led by Bertarelli and comprising Hansjörg Wyss, the École Polytechnique Fédérale de Lausanne (EPFL) and the University of Geneva had been successful in their bid for the former Merck Serono site in Geneva, which had been put up for sale when that company announced in April 2012 that it would be closing its Geneva headquarters. The name of the joint initiative is Campus Biotech and its intention is to turn the site into a ‘centre of excellence in the fields of healthcare, biotechnology and life sciences’. As part of this, the EPFL and the University of Geneva are expected to occupy some 15,000m2 of the site and, in October 2013, it was announced that Campus Biotech will be the core of a new Swiss neuroscience valley with the research groups involved in the Human Brain Project and the Blue Brain Project, as well as most scientists from the Center for Neuroprosthetics, moving there in 2014.

Bertarelli was awarded an Honorary Doctorate of Marine Sciences from Plymouth University in 2013.

Alinghi now competes in the Extreme Sailing Series, which it most recently won in 2016, and in the summer-long, one-class D35 championship on Lake Geneva.