On January 12, 2007, Domino was honored with OffBeat magazine's Lifetime Achievement Award at the annual Best of the Beat Awards, held at the House of Blues in New Orleans. New Orleans Mayor Ray Nagin declared the day "Fats Domino Day in New Orleans" and presented him with a signed declaration. Domino returned to stage on May 19, 2007, at Tipitina's at New Orleans, performing to a full house. This was his last public performance. The concert was recorded for a 2008 TV presentation entitled Fats Domino: Walkin' Back to New Orleans. This was a fund-raising concert, featuring a number of artists. Domino donated his fee to the cause. Later that year, a Vanguard record was released, Goin' Home: A Tribute to Fats Domino featuring his songs as recorded by Elton John, Neil Young, Tom Petty, Robert Plant, Willie Nelson, Norah Jones, Lenny Kravitz, and Lucinda Williams. A portion of the proceeds was to be used by the Foundation to help restore Domino's publishing office which had been damaged by the hurricane.
In September 2007, Domino was inducted into the Louisiana Music Hall of Fame.
In 2007, various artists came together for a tribute to Domino, recording a live session containing only his songs. Musicians performing on the album, Goin' Home: A Tribute to Fats Domino, included Paul McCartney, Norah Jones, Willie Nelson, Neil Young, and Elton John.