On 28 July 2010, Macheda scored his first goals of United's pre-season tour of North America as he netted twice in the 2010 MLS All-Star Game. The first came after just 21 seconds as he capitalised on a poor back-pass and the second came in the 13th minute with a header from a Nani corner kick. On 13 November 2010, Macheda scored his first goal of the season, netting United's first goal in a 2–2 away draw against Aston Villa.
Nicknamed Kiko, Macheda is a quick and versatile forward, who is capable of playing in a central role as a main striker, or in more of a supporting role as a second striker or attacking midfielder. Although naturally right-footed, he possesses an accurate and powerful shot with both feet, and is known in particular for his clinical finishing, intelligent movement, and ability to curl shots on goal from outside the area. He has been described as a "modern striker", as his technical skills, ability to read the game, and positional sense in the box, combined with his tall, large and strong physique, allow him to hold up the ball with his back to goal, retain possession under pressure, and create space for himself even in limited spaces and when being heavily marked by more physical opponents. Regarded as one of Italy's most promising prospects in his youth, in 2010 Don Balón included him in their list of the 100 best young players born after 1989; in recent seasons, however, he has often struggled to live up to his potential.