Đorđević was called up for the Serbia national team for 24 November 2007 Euro 2008 Group A qualifier at home against Kazakhstan, but did not make an appearance. Five years after his first call-up, Serbia head coach Siniša Mihajlović selected him for an exhibition match against Chile on 14 November 2012. He scored two minutes after entering the field as a substitute on his debut.

From the 2012–13 season, Đorđević exploded in form and directly contributed to Nantes’ promotion at the end of the season. Over 34 league games, he scored 20 goals and was the top scorer of Ligue 2 at the end of the season. On 16 August 2013, Lyon allegedly proposed between €3–5 million for Đorđević, although Đorđević and Nantes declined the transfer. In the club’s return to Ligue 1, Đorđević scored seven goals in the first 12 games, rivalling Radamel Falcao and Zlatan Ibrahimović for a top place in the Ligue’s list of high scorers of the season.

On 19 March 2014, Đorđević announced that he would be departing Nantes for Italian Serie A side Lazio. He signed a pre-contract agreement with Lazio after he entered the final six-months of his Nantes contract and joined the team on a free transfer on 1 July 2014. Đorđević’s first goals for Lazio came on 29 September 2014, scoring a hat-trick as the club defeated Palermo 4–0, lifting the club into the top half of the Serie A table. He scored again in the club’s next match, heading in an Antonio Candreva cross in the 25th minute, in a 3–2 home win over Sassuolo.

On 13 June 2018, Chievo have officially confirmed they’ll sign Đorđević when his contract expires on June 30. The contract signed by the Serbian will last three years with an optional extension for a fourth year.