Flavor Flav's House of Flavor in Las Vegas opened on the rapper's birthday in March 2012. Flavor Flav teamed up with Gino Harmon and Salvatore Bitonti to start a national franchise known as Flavor Flav's Chicken & Ribs, which opened December 21, 2012 in Sterling Heights, Michigan. The business was not affiliated with the previous two ventures Flavor Flav has had in the restaurant business. Flavor Flav's Chicken & Ribs was a casual dining experience with a quick serve attitude. Flavor Flav's Chicken & Ribs closed in July 2013 after being evicted by its landlord for failure to pay rent.
On January 10, 2012, Flav appeared with his longtime fiancée Liz on ABC's Celebrity Wife Swap. His fiancée traded places with Suzette, the wife of Twisted Sister front-man Dee Snider. On February 5, 2012, Flav appeared along with Elton John in a Pepsi Co. ad during Super Bowl XLVI. On February 11, 2012, Flav appeared as an honorary member of the UNLV Rebellion during the UNLV Runnin' Rebels victory over San Diego State, 65-63. From June to September 2012, Flav co-starred and rapped in the web series Dr. Fubalous. Flav has also appeared in YooHoo & Friends as Father Time.
On October 17, 2012, Flav was jailed in Las Vegas on felony charges stemming from a domestic argument with Trujillo and his threats to attack her teenage son, Gibran, with a knife.