In July 2010, Cobain debuted a collection of artwork titled Scumfuck under the pseudonym "Fiddle Tim" at the La Luz de Jesus Gallery in Los Angeles. On August 4, 2012, she participated in the group show 'MiXTAPE' under her real name. Artists were asked to pick a song and create art inspired by that song. Cobain chose the song "Black" by The Jesus and Mary Chain. The eclectic mix of songs chosen were featured for digital download on iTunes. Opening on June 7, 2017 through June 30, Cobain and artist Lindsey Way held a joint art exhibition titled "Ghosts For Sale" at Gallery 30 South in Pasadena.
Cobain appeared as a guest vocalist on the song "My Space" from the album Evelyn Evelyn by Evelyn Evelyn, which was released on March 30, 2010. Amanda Palmer from Evelyn clarified that Cobain was one of some 20 artists who sang the same line and whose voices were mixed together in the recording. Cobain was also an executive producer on the HBO movie about her father's life, Kurt Cobain: Montage of Heck. In 2019, she appeared as a special guest judge in one episode of RuPaul's Drag Race All Stars season 4.
On August 18, 2010, Cobain inherited 37% of her late father's estate. She now controls the publicity rights to her father's name and image instead of Love. Cobain has said she is not a fan of grunge bands, instead preferring the music of artists such as Oasis, The Brian Jonestown Massacre and Nina Simone, but she has said she likes the songs "Territorial Pissings" and "Dumb".