York's first screen role was in Robert Clarke's Hollywood exploitation film Secret File Hollywood shot in 1960 but not distributed until 1962. Her big break came when Jerry Lewis cast her in It's Only Money, in which she played a tantalizing sexpot, a role which brought her much publicity. This led to Lewis hiring her for five more of his films, including The Nutty Professor, The Patsy, The Disorderly Orderly, The Family Jewels, and Cracking Up, in which she portrayed a 15th-century marquise. Other film appearances include Bedtime Story, Tickle Me, Cannon for Cordoba, and science fiction cult films such as Curse of the Swamp Creature, Mutiny in Outer Space, and Space Probe Taurus. In The Doll Squad (1973), she played CIA agent Sabrina Kincaid. She portrayed Marilyn Monroe in Marilyn: Alive and Behind Bars, and in 2000, she played Nicolas Cage's mother-in-law in The Family Man.