In 1894, Picabia financed his stamp collection by copying a collection of Spanish paintings that belonged to his father, switching the originals for the copies, without his father’s knowledge, and selling the originals. Fernand Cormon took him into his academy at 104 boulevard de Clichy, where Van Gogh and Toulouse-Lautrec had also studied. From the age of 20, he lived by painting; he subsequently inherited money from his mother.

Around 1911 Picabia joined the Puteaux Group, members of which he met at the studio of Jacques Villon in Puteaux; a commune in the western suburbs of Paris. There he became friends with artist Marcel Duchamp and close friends with Guillaume Apollinaire. Other group members included Albert Gleizes, Roger de La Fresnaye, Fernand Léger and Jean Metzinger.

From 1913 to 1915 Picabia traveled to New York City several times and took active part in the avant-garde movements, introducing Modern art to America. When he landed in New York in June 1915, though it was ostensibly meant to be a simple port of call en route to Cuba to buy molasses for a friend of his—the director of a sugar refinery—the city snapped him up and the stay became prolonged.

Later, in 1916, while in Barcelona and within a small circle of refugee artists that included Albert Gleizes and his wife Juliette Roche, Marie Laurencin, Olga Sacharoff, Robert Delaunay and Sonia Delaunay, he started his Dada periodical 391 (published by Galeries Dalmau), modeled on Stieglitz’s own periodical. He continued the periodical with the help of Marcel Duchamp in the United States. In Zurich, seeking treatment for depression and suicidal impulses, he had met Tristan Tzara, whose radical ideas thrilled Picabia. Back in Paris, and now with his mistress Germaine Everling, he was in the city of “les assises dada” where André Breton, Paul Éluard, Philippe Soupault and Louis Aragon met at Certa, a Basque bar in the Passage de l’Opera. Picabia, the provocateur, was back home.

Picabia continued his involvement in the Dada movement through 1919 in Zürich and Paris, before breaking away from it after developing an interest in Surrealist art. (See Cannibale, 1921.) He denounced Dada in 1921, and issued a personal attack against Breton in the final issue of 391, in 1924.

In 1922, André Breton relaunched Littérature magazine with cover images by Picabia, to whom he gave carte blanche for each issue. Picabia drew on religious imagery, erotic iconography, and the iconography of games of chance.

In 1925, Picabia returned to figurative painting, and during the 1930s became a close friend of the modernist novelist Gertrude Stein. In the early 1940s he moved to the South of France, where his work took a surprising turn: he produced a series of paintings based on the nude glamour photos in French “girlie” magazines like Paris Sex-Appeal, in a garish style which appears to subvert traditional, academic nude painting. Some of these went to an Algerian merchant who sold them, and so it passed that Picabia came to decorate brothels across North Africa under the Occupation.

Before the end of World War II, he returned to Paris where he resumed abstract painting and writing poetry. A large retrospective of his work was held at the Galerie René Drouin in Paris in the spring of 1949. Francis Picabia died in Paris in 1953 and was interred in the Cimetière de Montmartre.

Among the artists influenced by Picabia’s work are the American artists David Salle and Julian Schnabel, the German artist Sigmar Polke, and the Italian artist Francesco Clemente. in 1996, French artist Jean-Jacques Lebel initiated and co-curated the exhibition Picabia, Dalmau 1922 (with reference to Picabia’s solo exhibition at Galeries Dalmau in 1922) shown at Fundació Antoni Tàpies in Barcelona and the Musée National d’Art Moderne, Centre Pompidou. In 2002, the artists Peter Fischli & David Weiss installed Suzanne Pagé’s retrospective devoted to Picabia at the musée d’art moderne de la ville de Paris (MAMVP). The Museum of Modern Art, New York, organized a major retrospective of his entire career, shown from 21 November 2016 to 19 March 2017.

In 2003, a Picabia painting once owned by André Breton sold for US$1.6 million.

On 16 November 2013, at Sotheby’s Impressionist & Modern Art Evening Sale in New York, Picabia’s Volucelle II (c. 1922, Ripolin on canvas, 198,5 x 249 cm) sold for US$8,789,000.