On April 7, 2019, Sánchez hit 3 home runs in one game against the Baltimore Orioles. On April 27, 2019, Sánchez hit his first career grand slam against the San Francisco Giants.
On May 19, 2019, Sánchez hit his first career triple against the Tampa Bay Rays.
On August 23 2019, Sánchez hit his 100th career homerun against the Los Angeles Dodgers making him the fastest catcher to hit 100 homeruns and second fastest player of all time to hit 100 homeruns.
On September 3, 2019, Sánchez broke his own franchise record by hitting two home runs (number 33 and 34), a winning effort against the Texas Rangers. He now has the two highest single-season home run totals ever for a Yankees catcher, as well as becoming the second with multiple 30-homer years, joining Yogi Berra.
In 2019, Sanchez dropped his passed balls from the league lead of 18 in 2018 to 7. However on defense he led all major league catchers in errors committed, with 15.