In 1924, Gershwin composed his first major classical work, Rhapsody in Blue, for orchestra and piano. It was orchestrated by Ferde Grofé and premiered by Paul Whiteman's Concert Band, in New York. It subsequently went on to be his most popular work, and established Gershwin's signature style and genius in blending vastly different musical styles in revolutionary ways.
Since the early 1920s Gershwin had frequently worked with the lyricist Buddy DeSylva. Together they created the experimental one-act jazz opera Blue Monday, set in Harlem. It is widely regarded as a forerunner to the groundbreaking Porgy and Bess. In 1924, George and Ira Gershwin collaborated on a stage musical comedy Lady Be Good, which included such future standards as "Fascinating Rhythm" and "Oh, Lady Be Good!". They followed this with Oh, Kay! (1926), Funny Face (1927) and Strike Up the Band (1927 and 1930). Gershwin allowed the song, with a modified title, to be used as a football fight song, "Strike Up The Band for UCLA".
Gershwin recorded an abridged version of Rhapsody in Blue with Paul Whiteman and his orchestra for the Victor Talking Machine Company in 1924, soon after the world premiere. Gershwin and the same orchestra made an electrical recording of the abridged version for Victor in 1927. However, a dispute in the studio over interpretation angered Whiteman and he left. The conductor's baton was taken over by Victor's staff conductor Nathaniel Shilkret.