|Name:||Gertrude B. Elion|
|Birth Day:||January 23, 1918|
|Death Date:||Feb 21, 1999 (age 81)|
|Birth Place:||New York City, United States|
Pioneer pharmacologist who was awarded the 1988 Nobel Prize in Physiology and Medicine for developing new drugs leukemia, gout, and malaria among others. Gertrude B. Elion became the first woman to be inducted into the National Inventors Hall of Fame in 1991.
As per our current Database, Gertrude B. Elion died on Feb 21, 1999 (age 81).
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Gertrude B. Elion earned her masters degree from New York University in 1941.
Elion was born in New York City on January 23, 1918, to parents Robert Elion, a Lithuanian Jewish immigrant and a dentist, and Bertha Cohen, a Polish immigrant. Her family lost their wealth after the Wall Street Crash of 1929. Elion was an excellent student who graduated from Walton High School at the age of 15. When she was 15, her grandfather died of stomach cancer, and being with him during his last moments inspired the multi talented Gertrude to pursue a career in science and medicine in college. She was Phi Beta Kappa at Hunter College, which she was able to attend for free due to her grades, graduating summa cum laude in 1937 with a degree in chemistry. Unable to find a paying research job after graduating because she was female, Gertrude worked as a secretary and high school teacher before working in an unpaid position at a chemistry lab. Eventually, she saved up enough money to attend New York University and she earned her M.Sc. in 1941, while working as a high school teacher during the day. In an interview after receiving her Nobel Prize, she stated that she believed the sole reason she was able to further her education as a young female was because she was able to attend Hunter College for free. Her fifteen financial aid applications for graduate school were turned down due to gender bias, so she enrolled in a secretarial school, where she attended only six weeks before she found a job.
Soon after graduating from Hunter College, Elion met Leonard Canter, an outstanding statistics student at City College of New York (CCNY). They planned to marry, but Leonard became ill. On June 25, 1941, he died from bacterial endocarditis, an infection of his heart valves. In her Nobel interview, she stated that this furthered her drive to become a research scientist and pharmacologist.
Unable to obtain a graduate research position, she worked as a food quality supervisor at A&P supermarkets and for a food lab in New York, testing the acidity of pickles and the color of egg yolk going into mayonnaise. She moved to a position at Johnson & Johnson that she hoped would be more promising, but ultimately involved testing the strength of sutures. In 1944, she left to work as an assistant to George H. Hitchings at the Burroughs-Wellcome pharmaceutical company (now GlaxoSmithKline) in Tuckahoe, New York. Hitchings was using a new way of developing drugs, by intentionally imitating natural compounds instead of through trial and error. Specifically, he was interested in synthesizing antagonists to nucleic acid derivatives, with the goal that these antagonists would integrate into biological pathways. He believed that if he could trick cancer cells into accepting artificial compounds for their growth, they could be destroyed without also destroying normal cells.Gertrude synthesized anti-metabolites of purines, and in 1950, she developed the anti-cancer drugs tioguanine and mercaptopurine.
Elion never married or had children. However, her brother, whom she was close with, married and had two sons and a daughter that she took pride in being able to watch grow. She listed her hobbies as photography, travel, opera and ballet, and listening to music. After Burroughs Wellcome moved to Research Triangle Park in North Carolina, Elion moved to nearby Chapel Hill. She retired in 1983 from Burroughs Wellcome to spend more time traveling and attending the opera. She continued to make important scientific contributions after her retirement. One of her passions during this time was encouraging other women to pursue a career in science.
While Elion had many jobs to support herself and put herself through school, Elion had also worked for the National Cancer Institute, American Association for Cancer Research, and World Health Organization, among other organizations. From 1967 to 1983, she was the Head of the Department of Experimental Therapy for Burroughs Wellcome. She officially retired from Burroughs and Wellcome in 1983.
In 1988 Elion received the Nobel Prize in Physiology or Medicine, together with Hitchings and Sir James Black for discoveries of "important new principles of drug treatment". Elion was the fifth female Nobel laureate in Medicine and the ninth in science in general, and one of only a handful of laureates without a doctoral degree. She was the only woman honored with a Nobel Prize that year. She was elected a member of the National Academy of Sciences in 1990, a member of the Institute of Medicine in 1991 and a Fellow of the American Academy of Arts and Sciences also in 1991.
She pursued graduate studies at night school at New York University Tandon School of Engineering (then Brooklyn Polytechnic Institute), but after several years of long-range commuting, she was informed that she would no longer be able to continue her doctorate on a part-time basis, but would need to give up her job and go to school full-time. Elion made a critical decision in her life, and stayed with her job and give up the pursuit of her doctorate. She never obtained a formal Ph.D., but was later awarded an honorary Ph.D. from New York University Tandon School of Engineering (then Polytechnic University of New York) in 1989 and an honorary S.D. degree from Harvard University in 1998.
Her awards include the Garvan-Olin Medal (1968), the Sloan-Kettering Institute Judd Award (1983), the American Chemical Society Distinguished Chemist Award (1985), the American Academy of Achievement's Golden Plate Award (1989), the American Association of Cancer Research Cain Award (1985), the American Cancer Society Medal of Honor (1990), the National Medal of Science (1991), and the Lemelson-MIT Lifetime Achievement Award (1997). In 1991 Elion became the first woman to be inducted into the National Inventors Hall of Fame. She was inducted into the National Women's Hall of Fame also in 1991. In 1992, she was elected to the Engineering and Science Hall of Fame. She was elected a Foreign Member of the Royal Society (ForMemRS) in 1995.
Gertrude Elion died in North Carolina in 1999, aged 81.
Even after her retirement from Burroughs Wellcome, Gertrude continued almost full time work at the lab. She played a significant role in the development of AZT, one of the first drugs used to treat HIV and AIDS. She also was crucial in the development of Nelarabine, which she worked on until her death in 1999.
Currently, Gertrude B. Elion is 103 years, 7 months and 26 days old. Gertrude B. Elion will celebrate 104th birthday on a Sunday 23rd of January 2022.
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