Deleuze was born into a middle-class family in Paris and lived there for most of his life. His initial schooling was undertaken during World War II, during which time he attended the Lycée Carnot. He also spent a year in khâgne at the Lycée Henri IV. During the Nazi occupation of France, Deleuze’s older brother, Georges, was arrested for his participation in the French Resistance, and died while in transit to a concentration camp. In 1944, Deleuze went to study at the Sorbonne. His teachers there included several noted specialists in the history of philosophy, such as Georges Canguilhem, Jean Hyppolite, Ferdinand Alquié, and Maurice de Gandillac. Deleuze’s lifelong interest in the canonical figures of modern philosophy owed much to these teachers.

Deleuze passed the agrégation in philosophy in 1948, and taught at various lycées (Amiens, Orléans, Louis le Grand) until 1957, when he took up a position at the University of Paris. In 1953, he published his first monograph, Empiricism and Subjectivity, on David Hume. This monograph was based on his 1947 DES (diplôme d’études supérieures [fr]) thesis, roughly equivalent to an M.A. thesis, which was conducted under the direction of Jean Hyppolite and Georges Canguilhem. From 1960 to 1964, he held a position at the Centre National de Recherche Scientifique. During this time he published the seminal Nietzsche and Philosophy (1962) and befriended Michel Foucault. From 1964 to 1969, he was a professor at the University of Lyon. In 1968, Deleuze defended his dissertations amid the ongoing May 68 demonstrations, and later published his two dissertations, Difference and Repetition (supervised by Gandillac) and Expressionism in Philosophy: Spinoza (supervised by Alquié).

Deleuze, who had suffered from respiratory ailments from a young age, developed tuberculosis in 1968 and underwent lung removal. He suffered increasingly severe respiratory symptoms for the rest of his life. In the last years of his life, simple tasks such as writing required laborious effort. On 4 November 1995, he committed suicide, throwing himself from the window of his apartment.

In 1969, he was appointed to the University of Paris VIII at Vincennes/St. Denis, an experimental school organized to implement educational reform. This new university drew a number of well-known academics, including Foucault (who suggested Deleuze’s hiring) and the psychoanalyst Félix Guattari. Deleuze taught at Paris VIII until his retirement in 1987.

The Logic of Sense, published in 1969, is one of Deleuze’s most peculiar works in the field of epistemology. Michel Foucault, in his essay “Theatrum Philosophicum” about the book, attributed this to how he begins with his metaphysics but approaches it through language and truth; the book is focused on “the simple condition that instead of denouncing metaphysics as the neglect of being, we force it to speak of extrabeing”. In it, he refers to epistemological paradoxes: in the first series, as he analyzes Lewis Carroll’s Alice in Wonderland, he remarks that “the personal self requires God and the world in general. But when substantives and adjectives begin to dissolve, when the names of pause and rest are carried away by the verbs of pure becoming and slide into the language of events, all identity disappears from the self, the world, and God.”

In his 1990 essay “Postscript on the Societies of Control” (“Post-scriptum sur les sociétés de contrôle”), Deleuze builds on Foucault’s notion of the society of discipline to argue that society is undergoing a shift in structure and control. Where societies of discipline were characterized by discrete physical enclosures (such as schools, factories, prisons, office buildings, etc.), institutions and technologies introduced since World War II have dissolved the boundaries between these enclosures. As a result, social coercion and discipline have moved into the lives of individuals considered as “masses, samples, data, markets, or ‘banks’.” The mechanisms of modern societies of control are described as continuous, following and tracking individuals throughout their existence via transaction records, mobile location tracking, and other personally identifiable information.

In the 1960s, Deleuze’s portrayal of Nietzsche as a metaphysician of difference rather than a reactionary mystic contributed greatly to the plausibility and popularity of “left-wing Nietzscheanism” as an intellectual stance. His books Difference and Repetition (1968) and The Logic of Sense (1969) led Michel Foucault to declare that “one day, perhaps, this century will be called Deleuzian.” (Deleuze, for his part, said Foucault’s comment was “a joke meant to make people who like us laugh, and make everyone else livid.”) In the 1970s, the Anti-Oedipus, written in a style by turns vulgar and esoteric, offering a sweeping analysis of the family, language, capitalism, and history via eclectic borrowings from Freud, Marx, Nietzsche, and dozens of other writers, was received as a theoretical embodiment of the anarchic spirit of May 1968. In 1994 and 1995, L’Abécédaire de Gilles Deleuze, an eight-hour series of interviews between Deleuze and Claire Parnet, aired on France’s Arte Channel.