Girish Karnad was born in Matheran, in present-day Maharashtra, in 1938. His mother Krishnabai née Mankikar was a young widow with a son who belonged to a poor family. Since it was necessary for her to earn a living, she began working as a nurse and cook (general housekeeper) for the bedridden wife of a certain Dr. Raghunath Karnad, a doctor in the Bombay Medical Services.

When Karnad started writing plays, Kannada literature was highly influenced by the renaissance in Western literature. Writers would choose a subject that looked entirely alien to manifestation of native soil. C. Rajagopalachari’s version of the Mahabharata published in 1951, left a deep impact on him and soon, sometime in the mid-1950s, one day he experienced a rush of dialogues by characters from the Mahabharata in Kannada.

He earned his Bachelor of Arts degree in mathematics and statistics from Karnatak Arts College, Dharwad (Karnataka University), in 1958. After graduation, he went to England and studied Philosophy, Politics and Economics at Magdalen in Oxford as a Rhodes Scholar (1960–63), earning his Master of Arts degree in philosophy, political science and economics. Karnad was elected the President of the Oxford Union in 1962–63.

“I could actually hear the dialogues being spoken into my ears … I was just the scribe,” said Karnad in a later interview. Yayati was published in 1961, when he was 23 years old. It is based on the story of King Yayati, one of the ancestors of the Pandavas, who was cursed into premature old age by his preceptor, Shukracharya, who was incensed at Yayati’s infidelity.

Karnad found a new approach of drawing historical and mythological sources to tackle contemporary themes and existentialist crisis of modern man through characters locked in psychological and philosophical conflicts. His next was Tughlaq (1964), about a rashly idealist 14th-century Sultan of Delhi, Muhammad bin Tughluq, and allegory on the Nehruvian era which started with ambitious idealism and ended up in disillusionment. This established Karnad, now 26 years old, as a promising playwright in the country. It was staged by the National School of Drama Repertory under the direction of Ebrahim Alkazi, with the actor Manohar Singh, playing the visionary king who later becomes disillusioned and turns bitter, amidst the historic Purana Qila in Delhi. It was staged in London by the National School of Drama for the Festival of India in 1982.

He was a proponent of multi-culturalism and freedom of expression. He was a critic of religious fundamentalism. He had publicly condemned the demolition of Babri Masjid in 1992 and later spoke against the attempts to create controversy about the Idgah Maidan in Hubli. He had opposed RSS, BJP and other organizations on several occasions. He opposed Narendra Modi for the Prime Minister’s post in the 2014 parliament elections. He was one of the 200 writers who put out an open letter against hate politics and for “diverse and equal India” during the 2019 general elections. With a tube in his nose, he wore a placard saying “Me Too Urban Naxal” at the first death anniversary of slain journalist Gauri Lankesh. Karnad claimed that Tipu Sultan was the greatest king Karnataka had in 500 years, on a religious controversy about the king. Karnad was a supporter of the Forum for Communal Harmony.

At the Tata Literary Festival held in Mumbai in 2012, Karnad was invited to speak about “his life in theater” in an hour-long session. Instead of talking about the subject, he took the opportunity to lash out at V. S. Naipaul for his “antipathy towards Indian Muslims”. V. S. Naipaul had earlier been conferred the Lifetime achievement award by the festival’s organisers. Karnad also criticized the organizers for having honored Naipaul.

In November 2015, during celebrations marking the anniversary of 18th-century Muslim ruler Tipu Sultan’s birth, Karnad stated that Bangalore International Airport should have been named after Tipu Sultan instead of Kempe Gowda. This created a furore among many people. Karnad apologised the following day.

Karnad died on 10 June 2019 at Bengaluru at the age of 81 due to multiple organ failure following prolonged illness.