In May 2013, GloZell released her first single, titled "Pick Up After Your Dog", on the iTunes Store, and the music video was soon released on YouTube. She released her second single, "Glozell's Cinnamon Challenge", later in May. By 2013, GloZell's YouTube channel had received more than 400 million total views, with 2.7 million subscribers, and was ranked the 25th most viewed comedy channel on YouTube. By 2015, the channel had accumulated more than 4 million subscribers and more than 700 million views.
GloZell was married from 2000 to 2003. She described her relationship with her ex-husband and their divorce in her autobiography Is You Okay?. GloZell lives in Los Angeles with her manager and husband Kevin Simon. The two got married on August 9, 2013. On August 4, 2016, GloZell and her husband welcomed their first child, via surrogate, naming their daughter O'Zell Gloriana De Green Simon. In 2020, Glozell announced that she has divorced her husband.