On September 23, 2007, Jennings caught a game-winning 57-yard TD pass from Favre with less than two minutes to play to help beat the San Diego Chargers 31–24 at Lambeau Field and improve the team's record to 3–0 in 2007. This was Jennings' first touchdown catch in 2007, as well as Favre's 420th career touchdown pass, tying him with Marino for the most TD passes in NFL history.
A week later on September 30, 2007, during a 23–16 victory over the Minnesota Vikings, Jennings caught a 16-yard pass from Favre that opened the scoring ten minutes into the first quarter, and broke the all-time touchdown pass record Favre had shared with Dan Marino. On October 29, 2007, Jennings caught an 82-yard touchdown pass from Favre to defeat the Denver Broncos 19–13 in overtime, tying him for the second-longest overtime touchdown in NFL history. Then the following week, he caught the game-winning touchdown pass that went for 60 yards to beat the Chiefs in Kansas City. Against the Cowboys on November 29, 2007, in a game broadcast on the NFL Network, Jennings hauled in the first ever touchdown pass by quarterback Aaron Rodgers.
Jennings and running back Ryan Grant each had a touchdown during a 33–14 victory over the St. Louis Rams on December 16, 2007, making it the first time two Packers players have each scored a touchdown in the same four consecutive games. Jennings collected 80 receptions for 1292 yards and 9 touchdowns in the 2008 season.