Homem-Christo was born on 8 February 1974 in Neuilly-sur-Seine. He is the great-great-grandson of Portuguese military figure Francisco Manuel Homem Cristo, who was forced into exile in France in 1910. Homem-Christo was given a toy guitar and keyboard at around seven years of age. He was eventually given an electric guitar at age 14, and uses a guitar when writing music.

Homem-Christo met Thomas Bangalter when they were attending the Lycée Carnot school together in 1987. It was there that they discovered their mutual fascination for films and music of the 1960s and 70s, “very basic cult teenager things, from Easy Rider to the Velvet Underground”. The two and Laurent Brancowitz eventually joined to form an indie rock trio called Darlin’, in which Homem-Christo performed guitar. Bangalter felt that “It was still maybe more a teenage thing at that time. It’s like, you know, everybody wants to be in a band.” A negative review referred to their music as “a daft punky thrash”, which inspired Bangalter and Homem-Christo’s new name. The two soon became interested in electronic dance music after going to a club in 1992. Homem-Christo is credited for designing the Daft Punk logo in the liner notes of Homework.

He produced Sébastien Tellier’s 2008 album titled Sexuality. In 2010, Homem-Christo worked with SebastiAn on the Kavinsky song “Nightcall”. In 2012, he was featured on Tellier’s album My God Is Blue on the track “My Poseidon.”

Following the release of Daft Punk’s fourth album Random Access Memories, Homem-Christo and Bangalter collaborated on two tracks with The Weeknd, “Starboy” and “I Feel It Coming,” with the former gaining the duo their first number one on the Billboard Hot 100 and the latter, co-written by Chedeville of Le Knight Club, peaking at number four. Homem-Christo worked on the title track to Charlotte Gainsbourg’s fifth studio album Rest, released in 2017. He also contributed to the 2018 song “Hurt You”, a collaboration with The Weeknd and Gesaffelstein.

In 2020, during the coronavirus pandemic, Homem-Christo created a curated playlist called “Star of a hero” for Italian brand MEDEA, containing tracks from the Beach Boys, The Weeknd, George Duke, and Thundercat, among others.